Protective effects of syringin against reproductive system injury induced by low dose radiation in mice

doi:10.19803/j.1672-8629.20220079

Abstract

Abstract: Objective To explore the protective effects of syringin against reproductive system injury induced by low dose radiation in mice. Methods A injury model was established after five consecutive days of low dose radiation (0.12 Gy·d^-1×5 d, cumulative 0.6 Gy). A control group (NC), radiation group (R), low dose administration group (syringin 10 mg·kg^-1), high dose administration group (syringin 20 mg·kg^-1) were established. The contents of serum cytokines (IL-1β, IL-6, IL-10, and TNF-α) and testosterone in the mice 24 h and 48 h after irradiation were determined by ELISA, and the levels of oxidative stress (MDA content, SOD activity, and GSH content) in the testis were determined by the kit. Results 24 h and 48 h after irradiation, the cytokine disorders in the testis of mice were significantly regulated, the oxidative stress level improved, and the testosterone level restored in the syringin administration group compared with the irradiation group. Conclusion Syringin can improve cytokine regulation disorders induced by low dose radiation in mice, reduce the damage to the reproductive system in mice effectively, and might be used as a potential protective drug against reproductive system damage in case of low dose radiation.

Key words: syringin, low dose radiation, mice, testicles, protective effect, reproductive system, injury

CLC Number:

R979.6

HU Changkun, ZHANG Xuemei, XIAO Chengrong, WANG Yuguang, MA Zengchun, GAO Yue. Protective effects of syringin against reproductive system injury induced by low dose radiation in mice[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 277-281.

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