The role of MRPs transporters in drug-induced liver injury

doi:10.19803/j.1672-8629.20230152

Abstract

Abstract: The liver is the organ with the most active metabolic activity in the human body, and is also responsible for the detoxification of numerous drugs. Prolonged or excessive use of drugs may lead to drug-induced liver injury (DILI), making drug transporters a key area of investigation in DILI research. Multidrug resistance-associated-proteins (MRPs) are proteins found on the cell membrane and are responsible for multidrug resistance. They are capable of transporting multiple drugs and play important role in DILI. Inhibition and removal of drug transporter activity is a major contributor to drug-induced liver damage. This article concludes and integrates the structure, expression sites, and functions of MRPs, and summarizes the relationship between MRPs and DILI, as well as the mechanisms for improving DILI In order to better understand the relationship between MRPs transporters and DILI, and provide reference for the prevention and treatment of DILI in the future.

Key words: multidrug resistance-associated-proteins, drug-induced liver injury, nuclear factor related receptor, transport

CLC Number:

R994.11

WANG Xin, SHI Leilei, ZHANG Yuhan, XIE Yundong, LIU Jiping. The role of MRPs transporters in drug-induced liver injury[J]. Chinese Journal of Pharmacovigilance, 2024, 21(2): 229-234.

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