Therapeutic effect of Foshao granules in mice with functional abdominal pain

doi:10.19803/j.1672-8629.20230285

Abstract

Abstract: Objective To clarify the therapeutic effect of Foshao granules in mice with spastic abdominal pain, and provide basic research data support for clinical application. Methods Experimental mice were randomly divided into seven groups according to their body weight: the normal control group, model control group, Domperidone control group (12 mg·kg^-1), Sini Powdered control group (3 g·kg^-1), Foshao granules high dosage group (48 g crude drug·kg^-1), Foshao granules middle dosage group (24 g crude drug·kg^-1), Foshao granules low dosage group (12 g crude drug·kg^-1), with 10 mice in each group. A cold stagnation functional abdominal painmedical syndrome combination model made by cold stimulation combined with an intraperitoneal injection of formalin. The therapeutic effect of mice with spastic abdominal pain induced by neostigmine was evaluated with the pain latency, the pain incidence, duration of pain, the pathological changes in the colon of the mice. Results The Foshao granules can significantly reduce the incidence of pain, prolong the pain incubation (P<0.05, P<0.01), shorten the pain length, and reduce the mucosal hyperplasia, and the enlargement and increase of goblet cells in the interstitial inflammation machine in the colon. Conclusion The Foshao granules significantly improved cold stimulation combined with formalin-induced functional abdominal pain in mice, providing a reference for the clinical application of Foshao granules.

Key words: neostigmine, spastic abdominal pain, Foshao granules, therapeutical effect, mice

CLC Number:

R994.1

LI Shuran, GUO Shanshan, BAO Lei, SUN Jing, ZHAO Ronghua, BAO Yanyan, GENG Zihan, ZHANG Yu, CAO Shan, LYU Yaozhong, WANG Zhenzhong, CUI Xiaolan, WANG Hongmei. Therapeutic effect of Foshao granules in mice with functional abdominal pain[J]. Chinese Journal of Pharmacovigilance, 2024, 21(3): 269-272.

Add to citation manager EndNote|Ris|BibTeX

URL: https://www.zgywjj.com/EN/10.19803/j.1672-8629.20230285

https://www.zgywjj.com/EN/Y2024/V21/I3/269

References

[1] LAURIE K, DOUGLAR AD, ELESPETH G, et al.Centrally mediated disorders of gastrointestinal pain[J]. Gastroenterology, 2016, 150(6): 1408-1419.
[2] FU JJ, WANG J, DUAN YH, et al.Meta-analysis of functional abdominal pain in children from spleen treatment prescription[J]. Journal of China-Japan Friendship Hospital(中日友好医院学报 ), 2021, 35(2): 102-104.
[3] NIKHIL T, MARC AB, MICHAEL DC, et al.Paediatric function abdominal pain disorders[J]. Nat Rev Dis Primers, 2020, 6(1): 89.
[4] KAPURAL L, GUPTA M, PAICIUS R, et al.Treatment of chronic abdominal pain with 10-kHz spinal cord stimulation: safety and efficaay results from a 12-Month prospective, multicenter, feasibility study[J]. Clin Transl Gastroenterol, 2020, 11(2): e133.
[5] DINAN TG, CRYAN JF.The microbiome-gut-brain axis in health and disease[J]. gastroenterol Clin North Am, 2017, 46(1): 77-89.
[6] GUO Y, SU XL, WEI W.Diagnosis and treatment progress of Chinese and western medicine in functional a bdominal pain syndrome[J]. Chinese Archives of Traditional Chinese Medicine(中国中医药学刊),2016,34(5): 1077-1080.
[7] MA JM, CHEN L.Research progress of TCM treatment for functional abdominal pain in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine(中国中西医结合儿科学), 2017, 9(4): 293-295.
[8] ZHAO WJ.Analysis of the predominant intestinal flora changes in patients with functional abdominal pain syndrome[D].Qingdao: University Of Qingdao(青岛大学), 2019.
[9] AGNETA U, JOHAN A, FRANK L, et al.Irritable bowel syndrome and functional abdominal pain in five-year-old children are related to lifestyle[J]. Acta Paediatr, 2016, 105(8): 971-978.
[10] HUANG MG, WANG JX, LUO F, et al.Pathogenesis of functional abdominal pain syndrome and research of traditional Chinese medicine intervention[J]. Journal of Liaoning University of Traditional Chinese Medicine(辽宁中医药大学学报), 2023, 25(7): 176-181.
[11] WANG QQ, ZHANG XL, LI MY, et al.Progress in TCM clinical studies of pediatric functional abdominal pain[J]. Journal of Hebei Traditional Chinese Medicine and Pharmacology(河北中医药学报), 2019, 34(3): 58-61.
[12] WEN TY, LIU XS.Professor Liu Xingshan's experience in treating and treating functional abdominal pain[J]. World Latest Medicine Information(世界最新医学信息文摘) , 2019, 19(28): 215.
[13] HOU F, SONG S.Clinical observation of 41 cases of functional abdominal pain and liver stagnation in children with integrated Chinese and Western medicine[J].Journal of Pediatrics of Traditional Chinese Medicine(中医儿科杂志), 2019, 15(3): 58-61.
[14] WANG JG, LI HN.From the "SuWen, The pain theory" on the lumbar disc herniation pain syndrome of massage syndrome treatment ideas[J]. Liaoning Journal of Traditional Chinese Medicine(辽宁中医杂志), 2015, 42(11): 2125-2127.
[15] HANG PJ, ZHANG D.Professor Zhang Di's experience in the treatment of functional abdominal pain in children extracted[J].Journal of Hunan University of Chinese Medicine(湖南中医药大学学报), 2020, 40(5): 613-616.