Effect of Foshao granules on spastic abdominal pain in rats

doi:10.19803/j.1672-8629.20230283

Abstract

Abstract: Objective To study the effects of Foshao granules on spastic abdominal pain in rats. Methods Six-week-old SD rats were divided into the normal control group, model group, domperidone control group（6.00 mg·kg^-1）, Sini powder control group（1.50 g·kg^-1） and Foshao granule groups (24 g crude drug·kg^-1, 12 g crude drug·kg^-1 and 6 g crude drug·kg^-1), with 10 mice in each. Spastic abdominal pain in rats was induced by intraperitoneal injection with neostigmine. The incubation, duration and incidence of pain as well as the pathological changes in the stomach and colon of the rats were observed, while serum contents of substance P, GT and MTL were detected by ELISA. Results Foshao granules could prolong pain incubation (P<0.05, P<0.01), shorten the pain duration (P<0.01), lower the incidence of pain, reduce the serum contents of substance P (P<0.01), GT (P<0.01), MTL (P<0.01), and inhibit mucosal hyperplasia, interstitial inflammation and the enlargement and increase of goblet cells in of the stomach and colon of rats. Conclusion Foshao granules can improve neostigmine-induced spastic abdominal pain.

Key words: Foshao granules, neostigmine, spastic abdominal pain, pesticide effect, rats

CLC Number:

R971
R994.1

LI Shuran, GUO Shanshan, BAO Lei, ZHAO Ronghua, SUN Jing, GENG Zihan, BAO Yanyan, ZHANG Jingsheng, XU Yingli, LYU Yaozhong, WANG Zhenzhong, CUI Xiaolan, WANG Hongmei. Effect of Foshao granules on spastic abdominal pain in rats[J]. Chinese Journal of Pharmacovigilance, 2024, 21(4): 404-407.

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