Mechanism of Potential Hepatotoxicity of Psoralea Corylifolia L. Based on Network Toxicology Analysis

doi:10.19803/j.1672-8629.2020.12.01

Abstract

Abstract: Objective To explore the mechanism of Psoralea corylifolia L. hepatotoxicity using network toxicology and molecular docking.Methods Literature on Psoralea Corylifolia L. was systematically retrieved, toxic components were screened by means of comparative toxicology genomics database (CTD) and admetSAR database, Psoralea Corylifolia targets were predicted by Pharmmapper server and GeneCards database before a toxic component-target interaction network was constructed by using Cytoscape software. Molecular docking validation was carried out on the binding of hub targets and toxic components by using SYBYL software, and finally GO biological function and KEGG pathway enrichment analysis was carried out by using the Metascape platform.Results Fourteen toxic components were screened from Psoralea Corylifolia L., involving 242 hepatotoxic targets. Molecular docking studies confirmed that the toxic components of Psoralea corylifolia L. had good binding activity to 10 hub targets. The results of network analysis showed that hepatotoxic targets of Psoralea Corylifolia L. were mainly related to such biological processes as cellular response to hormone stimuli, kinase activity, lipid binding and response peptide, cofactor metabolic process and to such signaling pathways as pathways in cancer, insulin signaling pathway, chemical carcinogenesis, PPAR signaling pathway, HIF-1 signaling pathway and Th17 cell differentiation.Conclusion The potential mechanism of Psoralea Corylifolia L. hepatotoxicity has been explored based on the multi-component, multi-target, and multi-pathway characteristics of traditional Chinese medicine, which brings new ideas for further research on the mechanism of Psoralea Corylifolia L. hepatotoxicity.

Key words: network toxicology, Psoralea Corylifolia L., hepatotoxicity, molecular docking

CLC Number:

R968

LIU Wei, QIN Ke, ZHANG Yanzhong, BAI Suping. Mechanism of Potential Hepatotoxicity of Psoralea Corylifolia L. Based on Network Toxicology Analysis[J]. Chinese Journal of Pharmacovigilance, 2020, 17(12): 849-855.

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