Research progress on material basis of liver toxicity of Polygonum multiflorum Thunb.

doi:10.19803/j.1672-8629.2022.06.06

Abstract

Abstract: Objective To analyze the material basis of liver toxicity of Polygonum multiflorum Thunb. based on related reports about the risk of liver injury caused by P. multiflorum. Methods Such databases as CNKI, Wangfang, VIP, PubMed and Web of Science were searched for literature related to the potentially hepatotoxic components of P. multiflorum reported over the past 25 years. Results Anthraquinones, stilbenes, naphthalene, mycotoxins from P. multiflorum might be the major hepatotoxic components that resulted in the "inherent hepatotoxicity" "idiosyncracy hepatotoxicity" "synergistic hepatotoxicity" and "liver toxicity caused by exogenous contaminants". Conclusion The material basis of liver injury caused by P. multiflorum is so complicated that the acute toxicity and mechanism of liver injury of these components need to be further studied in order to provide reference for the research on the hepatotoxicity of P. multiflorum and for rational use of P. multiflorum in clinic.

Key words: Polygonum multiflorum Thumb. inherent hepatotoxicity, material basis, idiosyncracy hepatotoxicity, synergistic hepatotoxicity, liver toxicity caused by exogenous contaminants

CLC Number:

R961
R969.3

YANG Jianbo, GAO Bowen, SUN Hua, JIN Hongtao, GAO Huiyu, NIU Hui, CHENG Xianlong, WANG Xueting, SONG Yunfei, WEI Feng, WANG Qi, WANG Ying, HU Xiaowen, MA Shuangcheng. Research progress on material basis of liver toxicity of Polygonum multiflorum Thunb.[J]. Chinese Journal of Pharmacovigilance, 2022, 19(6): 610-614.

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