Research progress on the animal models of idiosyncratic drug-induced liver injury

doi:10.19803/j.1672-8629.20230802

Abstract

Abstract: Objective To summarize the research on the animal models of IDILI, then to provide a scientific basis for guiding IDILI research and establishing its clinical risk prevention and control measures. Methods The research progress of IDILI model was discussed from various aspects, such as animal model, mathematical model and cellular model. Results and ConclusionIn recent years, IDILI has been gradually confirmed by researchers, and formed some hypothesis, such as Mitochondrial dysfunction hypothesis, Inflammatory stress hypothesis, immunological stress-mediated tri-elements synergetic mechanism hypothesis and genetic polymorphism hypothesis. Based on the characteristics of newly discovered “toxic” Chinese medicine-related IDILI, this team put forward the evaluation model and method of “disease-syndrome-based toxicology” of traditional Chinese medicine, on the basis of which it confirmed the problem of IDILI of Polygoni Multiflori Radix and other traditional Chinese medicines, and put forward the hypothesis of “toxicity due to three causes” mechanism of the immune stress of IDILI of traditional Chinese medicines, which better explained the characteristics of the pathogenesis of traditional Chinese medicines and the mechanism of IDILI.

Key words: idiosyncratic, hepatotoxicity, mechanism hypothesis, traditional Chinese medicine, disease-syndrome-based toxicology, assessment model, mitochondrial dysfunction hypothesis, inflammatory stress hypothesis, toxicity due to three causes

CLC Number:

R994.11

GAO Yuan, SHI Wei, XIAO Xiaohe, BAI Zhaofang, WANG Jiabo. Research progress on the animal models of idiosyncratic drug-induced liver injury[J]. Chinese Journal of Pharmacovigilance, 2024, 21(1): 33-39.

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