Research progress on the mechanism of hepatotoxicity associated with Polygonum multiflorum Thunb

doi:10.19803/j.1672-8629.2022.06.05

Abstract

Abstract: Objective To analyze the mechanism of hepatotoxicity and hepatotoxic substances of Polygonum multiflorum Thunb. Methods Reports on the mechanism of hepatotoxicity and controversial components of Polygonum multiflorum Thunb. were categorized, analyzed and summarized by consulting the literature. Results The hepatotoxicity of Polygonum multiflorum was specifically manifested in the functions and expressions of liver metabolic enzymes, the obstruction of bile metabolic circulation and functions of transporters, as well as immune stress and mitochondrial dysfunction. It was reported by literature that the possible toxic components were fat-soluble anthraquinones, characteristic distyrene glycosides, tannins and bianthrone compounds. It was speculated that the individual or synergistic effect of the above substances on the body might be related to the occurrence of hepatotoxicity. Conclusion It is possible that the hepatotoxicity of Polygonum multiflorum works via varied mechanisms. Related studies are expected to facilitate the research, development and safe applications of Polygonum multiflorum.

Key words: Polygonum multiflorum Thunb., hepatotoxicity, toxicity mechanism, anthraquinone, stilbene glycoside, ta-nnin, bianthrone

CLC Number:

R961
R969.3

LI Yanyi, ZHANG Yujie, WANG Qi, MA Shuangcheng. Research progress on the mechanism of hepatotoxicity associated with Polygonum multiflorum Thunb[J]. Chinese Journal of Pharmacovigilance, 2022, 19(6): 605-609.

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