Abstract: Objective To investgate the rationality of proton pump inhibitors (PPIs) use for outpatients in our hospital so as to regulate the rational clinical use of PPIs. Methods 4 392 outpatient prescriptions of PPIs were selected on the 10th and 20th of each month in 2015. The rationality of PPIs use was analyzed and evaluated in terms of indications, route of administration, solvent, usage, dosage, and combination of drugs by the standard of outpatient prescriptions for PPIs in our hospital. Results 1 074 irrational prescriptions were analyzed in 4 392 prescriptions, with irrationality ration of 24.39%. There are 1 145 unreasonable situations, including 856 cases of non-indicated use of drugs (accounting for 74.46%), 191 cases of improper combined use of drugs (accounting for 16.68%), 49 cases of inappropriate route of administration (accounting for 0.17%), 49 cases of solvent (accounting for 4.10%) and 2 cases of incorrect usage(accounting for 4.10%). Conclusion There exists an irrational situation of PPIs use in outpatients to a certain degree. Clinicians should master the indications of drug use seriously, pharmacists ought to pay more attention to censoring the prescriptions and contact with clinicians in time when discovering the irrational use of drugs.

Key words: proton pump inhibitor, prescription analysis, rational drug use