Abstract: Objective To investigate the incidence and clinical characteristics of drug-induced liver injury and provide reference for medication. Methods The medical records of drug induced liver injury collected from the hospital information management system between January 1, 2016 and December 31, 2019 were retrospectively analyzed. The basic information, biochemical indexes, clinical classification, grades of injuries, drugs involved, onset time, outcomes and therapeutic drugs were recorded. Results Fifty males and sixty-five females with a mean age of (57.98±16.64) years were enrolled in this study. Drug induced liver injury mostly occurred within 3 months of medication (n=74, 62.71%). The top three drugs were cardiovascular agents (n=38, 32.20%), traditional Chinese medicine (n=32, 27.12%) and endocrine drugs (n=13, 11.02%). Conclusion This study has found that females are more vulnerable to liver injury, and that cardiovascular drugs are most likely to lead to liver injury. Medical institutions should strengthen medical staff's training, advance their understanding of drug induced liver injury, and ensure active prevention, early identification and quick treatment for patients.

Key words: liver, adverse drug reaction, rational drug use