Abstract: Objective To analyze the common characteristics and rules of adverse drug reactions (ADRs) induced by mannitol injection, propose effective preventive measures of ADRs, and ensure medication safety of patients. Methods 137 cases of ADRs induced by mannitol injection from our center from July 1st, 2015 to September 30th, 2015 were analyzed in terms of genders and ages, symptoms, system-organs, time of occurring, new or serious ADRs. Results Most ADRs induced by mannitol injection occurred in patients over 46 years old, which happened equally between the male and the female. ADRs often occurred in patients with high doses. The main clinical manifestations of ADRs induced by mannitol injection involved urinary system disorders, skin and appendages disorders, nervous system disorders, and general disorders. ADRs mostly occurred within 30 min. Conclusion The usage and dosage in drug instructions for middle-old aged patients should be further improved, the medication of special groups should be paid more attention, clinical medication should be standardized and monitoring should be strengthened.

Key words: mannitol injection, adverse drug reaction