Research on the Acute and Mutagenic Toxic Effects of Yinsongxiang Compound

Abstract

Abstract: Objective To evaluate the acute and mutagenic toxic effects of Yinsongxiang compound. Chinese herbal active ingredient formula of Yinsongxiang compound was composed of Isatidis Radix, Lophatheri Herba, Chrysanthemi Flos, Lonicevae japonicae Flos extract and Glycyrrhizae Radix et Rhizoma extract. Methods Acute oral toxicity test, marrow cell micronucleus test（PCE）, marrow chromosomal aberration test of mice and Ames were tested. Results Mice acute oral MTD of the formula was higher than 15 g·kg^-1, and the micronucleus rates in all doses were not significantly different from the control group. Negative Results were seen from chromosome aberration test, and no increase in the number of revertant colonies was found in the Ames test with and without S9 activation system. Conclusion The Chinese herbal active ingredient formula has no toxic substance and mutagenicity effects in this study．

Key words: Chinese herbal, acute toxicity, mutagenicity, micronucleus, chromosomal aberration test, Ames test

CLC Number:

R965.3

WU Yan, DI Sha, LI Xian-yu, KONG Ran, AN Wan-LI, LI Zhi-hua, LIU Shao-hua, HUANG Dong-ye, TIAN Zhao-fu, YANG Hong. Research on the Acute and Mutagenic Toxic Effects of Yinsongxiang Compound[J]. Chinese Journal of Pharmacovigilance, 2016, 13(6): 321-324.

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