Total dosage of Chinese herbal pieces from changes of traditional Chinese medicine prescriptions

doi:10.19803/j.1672-8629.20210126

Abstract

Abstract: Objective To analyze the problems with the total dose of clinical prescriptions and the effects of dosage forms, extraction technology and dose-effect relationships on the total dose of prescriptions so as to provide reference for clinical rational use of drugs. Methods The daily dosage and prescribed daily dosage of different dosage forms of Chinese patent medicines prepared according to 10 classic prescriptions of traditional Chinese medicines in Volume One of Pharmacopoeia of People's Republic of China (2020 edition) were compared and analyzed. The factors that influenced the dosage of Chinese patent medicines were discussed in terms of extraction methods and dose-response relationships. Results The daily dosage and prescribed daily dosage of classical prescriptions included in the Pharmacopoeia varied widely after the drugs were made into different dosage forms. The prescribed daily dosage was basically within 100 g, and the daily dosage was considerably different between different dosage forms of Chinese patent medicines. Further analysis showed that the solvent selected, solvent dosage, temperature and time for extraction, drug particle size and extraction methods all had effects on the dissolution and total dose of prescriptions. Conclusion The total prescription dose of traditional Chinese medicines is closely related to the curative effect and drug safety. It is of great significance for clinicians to formulate a unified prescription dose standard for traditional Chinese medicines.

Key words: Chinese herbal pieces, total prescription dose, dosage form, traditional Chinese medicine prescriptions

CLC Number:

R924
944

LIU Tiantian, GONG Ying, GU Yuanyuan, HE Ting, ZHANG Zitong, CAO Junling. Total dosage of Chinese herbal pieces from changes of traditional Chinese medicine prescriptions[J]. Chinese Journal of Pharmacovigilance, 2022, 19(10): 1103-1106.

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