Chinese Journal of Pharmacovigilance ›› 2023, Vol. 20 ›› Issue (5): 560-567.
DOI: 10.19803/j.1672-8629.20230137

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Research hotspots and trends of herb-induced liver injury based on CiteSpace knowledge maps

XU Shuai1, CHEN Xun2, BIAN Haoyu1, ZHAO Yuqing1, ZHANG Liping1,*   

  1. 1Department of Gastroenterology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100029, China;
    2Department of Pediatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100090, China
  • Received:2023-03-10 Online:2023-05-15 Published:2023-05-16

Abstract: Objective To explore the development status and trend of herb-induced liver injury, and predict the future research direction by analyze the literature through visual analysis. Methods The research literature on herb-induced liver injury published from database inception to February 28, 2023 was retrieved from CNKI and Web of Science. CiteSpace 6.1.R6 was used to visually analyze the annual number of papers, authors, institutions and keywords, so as to discuss the research hotspots, status and development trends in this field. Results A total of 2 393 Chinese articles and 488 English articles were included, and the number of publications increased year by year with a stable trend. There were 71 core authors, forming several research teams, while there was little cooperation among them. Institutional cooperation is closer in English literature than in Chinese literature, and there are some cross-regional cooperations. Recent research focuses on the chemical components, mechanism, the toxicity reduction of TCM processing and compatibility, clinical evaluation, prevention and control of herb-induced liver injury. Conclusion The research popularity in the field of herb-induced liver injury has increased year by year, and exploring the mechanism and clinical evaluation indexes based on multi-omics technology may be the future focus of research.

Key words: liver injury, Chinese herbal medicine, CiteSpace, visualization analysis, bibliometrics

CLC Number: