Quality evaluation of Chaihu Shugan granules ria multi-component quantification combined with GRA and EW-TOPSIS method

doi:10.19803/j.1672-8629.20230173

Abstract

Abstract: Objective To establish a multi-component quantification combined with GRA and EW-TOPSIS method to evaluate the quality of Chaihu Shugan granules. Methods The determination was performed on a Shimadzu C₁₈ column with the mobile phase composed of acetonitrile-0.1% phosphoric acid. The contents of albiflorin, paeoniflorin, cyperenone, nootkatone, α-cyperone, saikosaponin A, saikosaponin D, naringin, hesperidin, neohesperidin, senkyunolide A, neocnidilide and ligustilide in Chaihu Shugan granules were calculated using the QAMS method. The models for quality evaluation of GRA and EW-TOPSIS in 18 batches of samples were constructed respectively, and the results of analysis were compared. Results The 13 components of Chaihu Shugan granules showed good linear relationships within their respective ranges (r≥0.999), and the average recoveries (n=9) ranged from 96.91% to 100.07%(RSD<2.0%). There was no obvious difference between QAMS and ESM(P>0.05). The relative correlation degree with the GRA method was 0.321 6-0.604 9, and the relative proximity with the EW-TOPSIS analysis method was 0.244 9-0.664 5. The overall results of evaluation by GRA and EW-TOPSIS models were basically the same. Conclusion This method can be used for quantitative control and quality evaluation of multi-components in Chaihu Shugan granules.

Key words: Chaihu Shugan granules, QAMS, GRA, EW-TOPSIS, quality evaluation

CLC Number:

R927
R994.11

LIU Kecheng, WEI Tanjun, CHEN Fei, XIAO Cheng, ZHANG Yinsu. Quality evaluation of Chaihu Shugan granules ria multi-component quantification combined with GRA and EW-TOPSIS method[J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1243-1248.

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