Chinese Journal of Pharmacovigilance ›› 2024, Vol. 21 ›› Issue (2): 163-166.
DOI: 10.19803/j.1672-8629.20230632

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Evaluation of the relevance of adverse drug reaction based on ERNIE-DPCNN

JIA Jinsheng1, LIU Hongliang1, WANG Qing2, HOU Yongfang1, LI Xinling1,*   

  1. 1Center for Drug Reevaluation, NMPA/NMPA, Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing 100076, China;
    2Research Center for Pharmacovigilance IT and Data Science, Tsinghua University, Tsinghua University, Beijing 100084, China
  • Received:2023-10-13 Online:2024-02-15 Published:2024-02-06

Abstract: Objective To establish a model for evaluation of ADR correlations in order to make the related evaluation more efficient and objective. Methods A total of 7 301 pieces of annotated data on adverse reaction reports obtained from literature and Internet sources were used for knowledge extraction to construct a knowledge graph about adverse drug reactions before a knowledge-driven automatic evaluation model of ERNIE-DPCNN relevance was established. Results The precision, recall and F1 value of the knowledge graph combined with the ERNIE-DPCNN model in the test set reached 82.18%, 81.40% and 81.21%, respectively, which yielded higher values than other models. Conclusion The method based on knowledge graphs combined with the ERNIE-DPCNN model can effectively improve the efficiency and accuracy of correlation evaluation of adverse drug reactions and reduce errors that arise from subjective evaluation, which is of referential value for automated evaluation based on artificial intelligence.

Key words: adverse drug reaction (ADR), ERNIE-DPCNN model, knowledge graph, correlations of evaluation, natural language processing, deep learning, artificial intelligence

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