Abstract: Objective To investigate the clinical characteristics, high-risk factors and treatment options of acute liver injury caused by tripterygium glycosides tablets on a case-by-case basis. Methods The clinical data on one case of pharmacogenic liver injury caused by tripterygium glycosides tablets used for chronic glomerulonephritis was analyzed based on related literature. Results A 34-year-old female patient with chronic glomerulonephritis was treated with tripterygium glycosides tablets 20 mg orally three times daily. She developed elevated ALT, AST, ALP and GGT before being given reduced glutathione combined with magnesium isoglycyrrhizate after discontinuation of tripterygium glycosides tablets. Her liver function indexes returned to normal after symptomatic treatment. Conclusion The clinical symptoms and biochemical indexes of liver function of patients should be monitored during treatment with tripterygium glycosides tablets to identify the possible pharmacogenic liver injury caused by traditional Chinese medicine. Patients with adverse reactions of liver injury should be given quick and corresponding treatment according to their conditions.

Key words: tripterygium glycosides tablets, drug induced liver injury, adverse drug reaction, case analysis