Abstract: Objective To analyze the clinical characteristics of anti-neoplastic drug induced liver injury (DILI). Methods The clinical data of 113 patients with DILI during anti-neoplastic therapy in Shuguang Hospital Affiliated to Shanghai University of TCM from January 1, 2021 to June 30, 2022 was retrospectively analyzed, including gender, age, disease history, primary tumor sites, anti-neoplastic therapy regimens, blood routine, liver and kidney function and tumor indicators. Chi-square test, t test and nonparametric test were used for analysis. Results Among the 113 patients with antitumor DILI, the ratio of males to females was 1.13∶1, and most of them were over 55 years old. In terms of primary tumor sites, the incidence of DILI was higher in patients with colon cancer (25.7%), lung cancer (13.3%), and gastric cancer (12.4%). Among antitumor therapy regimens, chemotherapy and targeted combined chemotherapy were most likely to cause DILI. As for the clinical classification of DILI, the proportion of patients with cholestasis was the highest (107 cases, 94.7%), followed by the mixed type (6 cases, 5.3%). The degree of liver injury was mostly mild (107 cases, 94.7%). Logistic regression analysis showed that alcohol consumption (OR 4.336, P=0.042) was an independent risk factor for antitumor DILI. Conclusion DILI caused by anti-neoplastic drugs mostly occur in elderly patients, and chemotherapy and targeted combination chemotherapy are the most common. Cholestasis is the dominating type. The degree of liver injury is relatively mild, and a previous history of alcohol consumption increases the risk of anti-neoplastic DILI.

Key words: tumor, anti-neoplastic drug, drug-induced liver injury(DILI), cholestatic, chemotherapy, targeted combination chemotherapy, clinical characteristics, risk factors, alcohol consumption