107 cases of liver injury caused by traditional Chinese medicines

doi:10.19803/j.1672-8629.20220330

Abstract

Abstract: Objective To analyze the characteristics of liver injury caused by traditional Chinese medicines in order to provide data for clinical medication. Methods The Pareto diagram was used to analyze 107 cases of liver injury caused by traditional Chinese medicines, which were recorded by Shandong Adverse Drug Reaction Monitoring System between 2018 and 2020. Results Among the 107 cases reported, males accounted for 57.94%. People aged 51 to 60 made up 29.91%. There were 11 types of traditional Chinese medicines that were found to cause liver injury. Desiccating formulas (34.59%) accounted for the largest proportion, followed by blood-regulating agents (25.24%) and heat-clearing agents (14.96%). Elevated levels of alanine aminotransferase and aspartate aminotransferase were the most common clinical symptoms. The shortest duration of medication was only one day (2 cases), and the longest was 2 years. The overall prognosis of liver injury was good, and no permanent liver injury or death was found in these reports. Conclusion Such ADR as liver injury induced by traditional Chinese medicines should be subject to more vigorous monitoring in order to reduce the incidence of liver injury and ensure the safety of medications.

Key words: traditional Chinese medicine, liver injury, adverse drug reaction, Pareto diagram analysis

CLC Number:

R994.11

WANG Guanjie, DU Shifang, LIU Baosheng, HAN Jiayan, WANG Zhenhua, LU Changfei. 107 cases of liver injury caused by traditional Chinese medicines[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 331-333.

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