Abstract: Objective To emphasize the standardized use of amlodipine in the elderly living alone, and to improve clinicians’ awareness of adverse drug reaction or overdose. Methods The clinical data of a case of multiple organ dysfunction syndrome (MODS) caused by amlodipine overdose in an old man living alone was analyzed, relevant case reports at home and abroad were reviewed, and the clinical features, treatment methods and prognosis were summarized. Results Amlodipine overdose may cause MODS, mainly manifested as slow heart rate, severe myocardial depression, hyperlactic acidemia, refractory shock, liver and kidney insufficiency, and the treatment method is to stop the responsible drug and support the organ function. Conclusion Amlodipine has the risk of MODS in special populations. For patients with MODS of unknown cause, we should be alert to the risk of adverse drug reactions or overdose poisoning. Early identification and corresponding treatment measures can improve the prognosis.

Key words: amlodipine, poisoning, multiple organ dysfunction syndrome, adverse drug reaction, plasma exchange, extracorporeal membrane oxygenation, overdose