Network pharmacology of bexarotene against cerebral ischemia-reperfusion injury

doi:10.19803/j.1672-8629.20210503

Abstract

Abstract: Objective To explore the mechanism of bexarotene in the treatment of cerebral ischemia reperfusion injury (CIRI) via network pharmacology. Methods PharmMapper Server was used to predict the targets of bexarotene, GeneCards was applied to retrieve the targets of the disease, and VENNY 2.1.0 was adopted to map the targets of bexarotene on CIRI. PPI networks of potential targets were constructed with software Cytoscape 3.8.2 before the R language package clusterProfiler was used for GO enrichment analysis and KEGG pathway analysis of the potential targets of bexarotene against CIRI. Results After mapping the predicted 275 targets of bexarotene with the 513 targets of cerebral ischemia/reperfusion injury, a total of 73 intersection targets were obtained. In the PPI network of potential targets, the top 10 key target genes were ALB, AKT1, CASP3, JUN, MAPK1, MAPK8, MMP9, SRC, IGF1 and ESR1. A total of 138 pathways were enriched by KEGG pathway analysis, among which the MAPK signaling pathway, apoptosis signaling pathway, PI3K-Akt signaling pathway, fluid shear stress and atherosclerosis signaling pathway were most significantly related to CIRI. Conclusion Bexarotene protects against CIRI possibly by acting on multiple targets and through multiple pathways, exerting anti-apoptotic, anti-inflammatory, anti-oxidant, anti-coagulative effects.

Key words: bexarotene, cerebral ischemia-reperfusion injury, network pharmacology

CLC Number:

R966
R743

SHI Qiang, LIU Shengwei, SHEN Zhengze, CHEN Chang, REN Zhongyang, LIU Jie, HU Yi. Network pharmacology of bexarotene against cerebral ischemia-reperfusion injury[J]. Chinese Journal of Pharmacovigilance, 2022, 19(12): 1332-1337.

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