Analysis of Drug Characteristics of Mailuoshutong Pill Treating Patients with Orthopedic and Surgical Disease in Real World

doi:10.19803/j.1672-8629.2021.08.03

Abstract

Abstract: Objective To find out about the clinical characteristics of combined use of Mailuoshutong pills in the treatment of orthopedic and surgical diseases. Methods Information about 3173 patients with orthopedic and surgical diseases who used Mailuoshutong pills at least once in the information system of 14 large tertiary hospitals in China between 2006 and 2016 was retrieved. The clinical characteristics of drug combination were described. Results The average age of these patients was (42.74±16.33) years old, and the ratio of males to females was 2.54∶1. The majority of patients were 18-45 years old (46.14%). Among the combined drugs, Honghua injection (9.77%) was most likely to be used with Mailuoshutong pills. Phenobarbital (6.4%) was the most common drug used in combination with one type of western medicine. Association rules showed the combination of one type of traditional Chinese medicine and one type of western medicine was usually between Xianling Gubao capsules and cefazolin (9.39%). The combination of one type of traditional Chinese medicine and two types of western medicines was usually between Xianling Gubao capsules and cefazolin and phenobarbital (8.54%). The combination of one type of traditional Chinese medicine and three types of western medicines normally involved Xianling Gubao capsules, cefazolin, phenobarbital and inosine (4.92%). Conclusion Mailuoshutong pills are often combined with such traditional Chinese medicines that can invigorate blood circulation and remove blood stasis, tonify the kidney and strengthen bones, invigorate the spleen and facilitate defecation. These pills are also often combined with western medicines that are sedative, painkilling, antibacterial, anti-inflammatory, acid suppressive and stomach-protecting. This study has provided data for clinical drug combination against orthopedic and surgical diseases. Further verification is needed to carry out clinical studies at a higher level of evidence.

Key words: Mailuoshutong pills, orthopedic and surgical disease, the real world, association rules

CLC Number:

R994.11

CHENG Fengjingming, WANG Lianxin, XIE Yanming, ZHUANG Yan. Analysis of Drug Characteristics of Mailuoshutong Pill Treating Patients with Orthopedic and Surgical Disease in Real World[J]. Chinese Journal of Pharmacovigilance, 2021, 18(8): 710-714.

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