Abstract: Objective To explore the combined drug use law of Elemene emulsion injection in the treatment of malignant tumors in the real world based on data mining technology. Methods 3 671 malignant tumor patients who had used elemene injection at least once were included in hospital information system (HIS) from January 1, 2003 to July 31, 2019. The statistical analysis was completed by R software. This paper describes the clinical characteristics of malignant tumor population, uses Apriori algorithm to analyze the association of combined drug regimens for malignant tumor patients, and uses Louvain clustering method to mine the complex network of core treatment regimens of 1 233 excellent effect people. Results There were 146 cases of missing sex records in patients with malignant tumors treated with elemene emulsion injection. Male (2 244 cases, 61.13%) was higher than female (1 281 cases, 34.90%). The patients aged 46~65 years were the most (1 705 cases, 46.45%). The most common diseases are lung cancer(4 145 cases, 15.95%), with hypertension and diabetes. The frequency of combined use of Western medicines was significantly higher than that of Chinese patent medicines. The top three Western medicines were vitamins, dexamethasone and insulin for injection, and the top three Chinese patent medicines were compound Sophora flavescens injection, Kang’ ai injection and Shenqi Fuzheng injection. Compound Matrine injection is the most used Chinese patent medicine. Association rule analysis showed that elemene emulsion injection combined with lidocaine and heparin had the highest support (46.46%), and the support of combined Chinese patent medicine is generally lower than that of combined Western medicine. The results of complex network analysis of dominant population showed that elemene emulsion injection combined with heparin had the highest weight. The core anti-tumor drug regimen was elemene injection combined with heparin, lidocaine and dexamethasone. In addition, it was often combined with therapeutic drugs for cardiovascular system, respiratory system and digestive system. Conclusion Elemene injection combined with surgery, radiotherapy and chemotherapy in the treatment of a variety of malignant tumors. The combined drug characteristics suggest that we should pay attention to the management of patients’ basic diseases, especially cardiovascular disease and blood glucose. For the common complications of tumor (such as nausea, vomiting, venous thrombosis, constipation, etc.), based on the symptomatic treatment of Western medicine, various Chinese patent medicines are selected according to syndrome differentiation to improve the quality of life of patients.

Key words: elemene emulsion injection, malignant tumor, the real world, combination medication, association rules, cluster analysis