A Real World Study on the Effect of Cervus and Cucumis Polypeptide Injection on Liver Function in Fractured Patients

doi:10.19803/j.1672-8629.2021.06.10

Abstract

Abstract: Objective To study the effect of cervus and cucumis polypeptide injection on liver function in fractured patients based on real-world medical electronic data. Methods The information about 12 847 fractured patients who received cervus and cucumis polypeptide injection (experimental group) and 12 619 fractured patients who did not between July 1, 2003 and December 31, 2014 (control group) was retrieved from the database of the hospital information system (HIS) and laboratory information management system (LIS) of 26 tertiary hospitals in China. Propensity score weighting using the generalized boosted model (GBM) was employed to control confounders, while Logistic regression was used to analyze whether there were statistically significant differences in liver function abnormalities between the two groups in the real world. Results The changes of liver function (ALT and AST) in the two groups were analyzed using Logistic regression following propensity score weighting. P values were all greater than 0.05, and the difference was not statistically significant. Conclusion Based on the available data and this analysis, cervus and cucumis polypeptide injection may not affect the liver function of patients with fractures.

Key words: cervus and cucumis polypeptide injection, abnormal liver function, propensity score, the real world

CLC Number:

R994.11

CHEN Fan, LI Yuanyuan, ZHANG Qing, XIE Yanming, GAO Minghui. A Real World Study on the Effect of Cervus and Cucumis Polypeptide Injection on Liver Function in Fractured Patients[J]. Chinese Journal of Pharmacovigilance, 2021, 18(6): 542-546.

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