Research Progress in Hepatotoxicity and Prevention and Treatment of Arsenic Trioxide

doi:10.19803/j.1672-8629.2020.03.11

Abstract

Abstract: Arsenic trioxide is used in the treatment of acute promyelocytic leukemia and other malignant tumors, to good effect. However, in recent years, arsenic trioxide has been found to have hepatotoxic effect, which limits its clinical application. There was the finding that the hepatotoxicity of arsenic trioxide was related to the increase of oxidative stress and the induction of apoptosis. In this paper, the mechanism of hepatotoxicity of arsenic trioxide and its prevention and treatment were reviewed.

Key words: arsenic trioxide, acute promyelocytic leukemia, hepatotoxicity, oxidative stress, apoptosis

CLC Number:

R595.2

SUN Jiafu, SUN Xiao, SUN Guibo, SUN Xiaobo, NAN Fengwei, LUO Yun, GAO Ye, WANG Shan. Research Progress in Hepatotoxicity and Prevention and Treatment of Arsenic Trioxide[J]. Chinese Journal of Pharmacovigilance, 2020, 17(3): 177-183.

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