Abstract: Objective To evaluate rationality of the clinical use of oxaliplatin in our hospital. Methods Using the hospital information system, we collected cases of oxaliplatin from April 2014 to March 2015, and analyzed the rationality and safety. Results The cases of oxaliplatin were 531 in total. 120 cases were randomly selected for analysis. Indications were consistent with the drug instructions in 55 cases (45.83%). 65 cases (54.17%) off-label use, but consistent with the guidelines recommendation. Improper dosing frequency for 6 cases (5%) and improper dosage of administration for 3 cases (2.5%) were observed. 64 cases had adverse reactions, mainly involving the digestive system for 30 cases (25.00%), hematopoietic system for 46 cases (38.33%) and the nervous system for 13 cases (10.83%). There also were one case of phlebitis and one case of skin rash. Conclusion Off-label use of oxaliplatin is common in our hospital, most of which is evidence-based. It is urgent to strengthen the management of antineoplastic drugs,conduct real-time tracking and information feedback, and promote rational drug use.

Key words: oxaliplatin, off-label use, dosage, adverse drug reaction