Abstract: Objective To explore the changes of insoluble particle numbers, pH value and clarity of Xuebijing injection in 5% glucose injection, 10% glucose injection, sodium chloride glucose injection and 0.9% sodium chloride injection respectively and to provide evidence for clinical application. Methods According to Chinese Pharmacopoeia (2010) appendix IVC, the changes of Xuebijing mixed solutions were observed in particle numbers, pH value and clarity in clinically used concentrations on 0, 0.5 , 2 , 4 , 8 h and 24 h at room temperature. Results The number of insoluble particles in glucose injection was less than that in 0.9% sodium chloride injection. The number of insoluble particles in 10% glucose injection was less than that in 5% glucose injection. The Xuebijing injection was more stable when blended with 10% glucose injection. At room temperature, there were no significant changes in clarity and pH value, RSD<2%. The result was up to the requirement of Chinese Pharmacopoeia (2010) appendix IVC. The number of insoluble particles in Xuebijing injection exceeded the standard of Chinese Pharmacopoeia (2010) appendix IVC after being blended with 0.9% sodium chloride injection. Conclusion The suitable solvent for Xuebijing injection is 10% glucose injection,secondly 5% glucose injection. The Xuebijing solution should be used in 4 h after being mixed with solvents.

Key words: Xuebijing injection, transfusion, compatibility, stability