Abstract: Abstract:Objective To analyze general regularity and characteristics of Mailuoning injection-induced ADRs,and provide references for clinical rational drug use. Methods Literatures about Mailuoning injection-induced ADRs published between 1992 and 2015 were retrieved,and 178 ADR cases reports were analyzed statistically. Results Mailuoning injection-induced ADRs had no association with gender,and often occurred in patients between 41~65 years old, 62.92% cases occurred within 30 mins after medication ,and the ADR cases mainly manifested as systemic damage and respiratory system damage. The main clinical manifestations were dyspnea and allergic shock. There were 2 death cases,and other patients recovered after symptomatic treatment. Conclusion Mailuoning injection can induce serious adverse reactions,and some kinds of ADRs were undescribed in instructions,so we should strengthen the medication monitoring and treating ADR timely to ensure the safety of patient medication.

Key words: Mailuoning injection, adverse drug reaction (ADR), literature analysis