Research progress in correlations between herpes simplex virus-1 and Alzheimer's disease and in the prevention and treatment of herpes simplex virus-1 with traditional Chinese medicine

doi:10.19803/j.1672-8629.20220363

Abstract

Abstract: Objective To review the pathological association between herpes simplex virus type I (HSV-1) and Alzheimer’s disease (AD), the possible mechanism and the role of traditional Chinese medicines in anti-HSV-1 infection. Methods CNKI and PubMed databases were searched for reports on the relationships between HSV-1 and Alzheimer’s disease and on the prevention and treatment of HSV-1 with traditional Chinese medicines and Western medicine that were published between January 1, 1990 and May 30, 2022. Results It was found that repeated HSV-1 infections induced the accumulation of β amyloid (Aβ) and the increase of p-Tau expressions. ApoE? gene facilitated the entry of HSV-1 into the brain and increased the risk of AD induced by HSV-1. Aβ might be an antimicrobial peptide that trapped HSV-1. Many of the monomers or compounds of traditional Chinese medicines had good anti-HSV-1 effect. Conclusion HSV-1 infection maybe one of the factors for the development of Alzheimer’s disease, and the mechanism may be related to the trapping of HSV-1 virus by Aβ. ApoE? gene increases the risk of HSV-1 induced Alzheimer’s disease. Some progress has been made in the study on anti-HSV-1 infection by traditional Chinese medicines, which provides strong support for screening new drugs against HSV-1 from traditional Chinese medicines.

Key words: herpes simplex virus-1, Alzheimer's disease, traditional Chinese medicine, immunologic system, nervous system, infection

CLC Number:

LI Shuran, GUO Shanshan, CUI Xiaolan. Research progress in correlations between herpes simplex virus-1 and Alzheimer's disease and in the prevention and treatment of herpes simplex virus-1 with traditional Chinese medicine[J]. Chinese Journal of Pharmacovigilance, 2023, 20(3): 258-261.

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