Component-effect/toxicity-target correlations of Tripterygium wilfordii in terms of lipid metabolism

doi:10.19803/j.1672-8629.20220734

Abstract

Abstract: Objective To analyze the lipid metabolic pathways related to the efficacy and/or toxicity of Tripterygium wilfordii’s and to explore the component-effect/toxicity-target correlations. Methods Recent literature on the regulation of lipid metabolism by Tripterygium wilfordii preparations and its active components was collected and reviewed. An analytical model for component-effect/toxicity-target correlations was established based on theories of pharmacology, clinical use and experimental research. Results Tripterygium wilfordii preparations and its active components proved to exert therapeutic effects by regulating multiple key processes of lipid metabolism, including fatty acid metabolism, phospholipid metabolism and steroid metabolism while inducing various toxic effects due to lipid peroxidation, phospholipid metabolism disorders and bile acid accumulation. Conclusion The analysis of the component-effect/toxicity-target correlations from perspective of lipid metabolism pathways can help to better understand and evaluate its effectiveness and safety, which will facilitate rational medications in clinical practice.

Key words: Tripterygium wilfordii, lipid metabolism, component-effect/toxicity-target correlations, fatty acid metabolism, phospholipid metabolism, steroid metabolism, theories of traditional Chinese medicine properties

CLC Number:

R961
R994.11

DING Zihe, ZHANG Yanqiong, LIN Na. Component-effect/toxicity-target correlations of Tripterygium wilfordii in terms of lipid metabolism[J]. Chinese Journal of Pharmacovigilance, 2023, 20(5): 489-495.

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