Research progress in Yi medicine Elephantopus scaber L. and predictive analysis of quality markers

doi:10.19803/j.1672-8629.20210311

Abstract

Abstract: Elephantopus scaber L. is a traditional Chinese medicine which contains a variety of chemical components and has the functions of clearing heat, cooling blood, detoxification and diuresis. In recent years, studies have found that it has a wide range of pharmacological effects, such as anti-tumor, anti-inflammatory, anti-virus and liver-protecting properties. In this paper, flavonoids, steroids, triterpenoids and sesquiterpene lactones in Elephantopus scaber L. were described and analyzed, and the pharmacological effects were summarized. Based on the concept of quality markers (Q-markers) of traditional Chinese medicines, the Q-markers of Elephantopus scaber L. were predicted and analyzed in terms of pharmaphylogeny, component specificity and traditional efficacy. It was speculated that sesquiterpene lactones flavonoids and triterpenoids in Elephantopus scaber L. could be used as quality markers for quality evaluation.

Key words: Elephantopus scaber L., sesquiterpene lactones, flavonoids, antineoplastic, anti-inflammatory, Q-Marker

CLC Number:

R927.11

GUO Jiahui, CAI Yuluo, ZHEN Yaqin, WANG Xinguo, NIU Liying, CHEN Zhong. Research progress in Yi medicine Elephantopus scaber L. and predictive analysis of quality markers[J]. Chinese Journal of Pharmacovigilance, 2022, 19(11): 1272-1276.

References

[1] ZHANG HB, KONG LJ, LIANG QL, et al.Studies on triterpenes from Elephantopus scaber[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2011, 17(3): 101-103.
[2] DONG CL.Studies on the chemical constituents and antibacterial effects of Elephantopus scaber L.[D]. Guangzhou: Guangdong Pharmaceutical University, 2016.
[3] GUO Y, CHEN C, GAO C, et al.Chemical constituents of Elephantopus scaber[J]. Natural Product Research and Development(天然产物研究与开发), 2016, 28(7): 1051-1054.
[4] WANG WC, JIANG C, ZHANG ZD, et al.Advances in modern pharmacological studies of Elephantopus scaber L.[J]. Strait Pharmaceutical Journal(海峡药学), 2020, 32(2): 46-49.
[5] CAO H, CHEN W, BI PX.An overview of the medicinal plants of the genus orchidaceae[J]. International Journal of Traditional Chinese Medicine[国外医学(中医中药分册)], 1998(2): 11-15.
[6] ZUO AX, RAO GX.Research progress on chemical constituents of elephantopus scaber linn. and their pharmacological effects[J]. China Pharmaceuticals(中国药业), 2014(17): 3-7.
[7] BUT PPH, HON PM, CAO H, et al.Sesquiterpenelactones from elephantopus scaber[J]. Phytochemistry, 1997, 44(1): 113-116.
[8] LUO JH, CUI LL, LI M, et al.Extraction, purification and antibacterial mechanism of total flavonoids from elephantopus scaber[J]. Science and Technology of Food Industry(食品工业科技), 2020, 41(18): 70-74.
[9] WU YF, LIU Y, LI M, et al.Optimization in water-extraction process of total flavonoids from Elephantopus scaber L.[J]. Chemistry & Bioengineering(化学与生物工程), 2019, 36(10): 24-26,50.
[10] GUO F, LIANG QL, MIN ZD.Study on the flavonoids in Elephantopus scaber L.[J]. Chinese Traditional and Herbal Drugs(中草药), 2002, 33(4): 303-304.
[11] HUANG T.Study on the chemical constituents of Elephantopus scaber L.[D]. Guangzhou: Jinan University, 2010.
[12] LIAO JH.Experimental study on the antitumor effect of triterpene extract from Elephantopus scaber L. on S180 mice in vivo[J]. Journal of Medicinal Chemistry(药物化学), 2018, 6(2): 37-41.
[13] LIANG QL, GONG ZA, MIN ZD.Studies on triterpenes from Elephantopus scaber L.[J]. Chinese Pharmaceutical Journal(中国药学杂志), 2007,4(7): 494-496.
[14] WANG B.Study on the bioactive components of Elephantopus tomentosus[D]. Haikou: Hainan University(海南大学), 2012.
[15] LI Y, ZHANG CY, LIN T, et al.Chemical constituents of Elephantopus tomentosus[J]. Chinese Journal of Chinese Materia Medica(中国中药杂志), 2013, 38(11): 1751-1756.
[16] ICHIKAWA K, SAKURAI Y, AKIYAMA T, et al.Isolation and stricture determination of alaose reductase inhibitors from traditional Thai medicine, and synthesis of their derivatives[J]. Sankyo Kenkyusho Nenpo, 1991, 43: 99.
[17] HUANG CC, LO CP, CHIU CY, et al.Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice[J]. Br J Pharmacol, 2010, 159(4): 856-871.
[18] SU M, CHUNG HY, LI Y.Deoxyelephantopin from Elephantopus scaber L.induces cell-cycle arrest and apoptosis in the human nasopharyngeal cancer CNE cells[J]. Biochem Biophys Res Commun, 2011, 411(2): 342-347.
[19] HE CG, DONG LW, RUAN XP, et al.Experimental study on antimicrobial and anti-inflammatory effects of extracts from whole Elephantopus scaber[J]. Chinese Journal of Traditional Medical Science and Technology(中国中医药科技), 2008, 15(3): 191-192.
[20] WEN XM, YANG MN, HU TK.Animal experimental study on anti - inflammatory and analgesic effects of water extract of Elephantopus scaber L.[J]. Yunnan Journal of Traditional Chinese Medicine and Materia Medica(云南中医中药杂志), 2015, 36(12): 71-72.
[21] KUMAR SS, PERUMAL P, SURESH B.Antibacterial studies on leaf extract of Elephantopus scaber Linn[J]. Ancient Science of Life, 2004, 23(3): 6.
[22] CHEN CP, LIN CC, NAMBA T.Screening of Taiwanese crude drugs for antibacterial activity against Streptococcus mutans[J]. J Ethnopharmacol, 1989, 27(3): 285-295.
[23] TSAI CC, LIN CC.Anti-inflammatory effects of Taiwan folk medicine Teng-Khia-U on carrageenan-and adjuvant-induced paw edema in rats[J]. J Ethnopharmacol, 1999, 64(1): 85-89.
[24] WANG B, MEI WL, ZUO WJ, et al.Analysis of liposoluble components from Elephantopus scaber and Elephantopus tomentosus by GC-MS and Studies on Antibacterial Function[J]. Natural Product Research and Development(天然产物研究与开发), 2012, 24(B12): 23-27.
[25] TAYLOR R, MANANDHAR N, HUDSON J, et al.Antiviral activities of Nepalese medicinal plants[J]. J Ethnopharmacol, 1996, 52(3): 157-163.
[26] GENG HW, ZHANG XL, WANG GC, et al.Antiviral dicaffeoylquinic acid derivatives from Elephantopus scaber[J]. Journal of Asian Natural Products Research, 2011, 13(7): 665-669.
[27] WIWAT C, KWANTRAIRAT S.HIV-1 reverse transcriptase inhibitors from thai medicinal plants and Elephantopus scaber Linn[J]. Mahidol University Journal of Pharmaceutical Sciences, 2014, 40(3): 35-44.
[28] ZHAO YJ, WANG ZY, DING WP.Pharmacognosy identification of the civil medicine Elephantopus scaber L.[J]. Chinese Medicine Chemistry(中药化学)1998, 11(2): 24-26.
[29] KUANG GK, LUO D, ZHANG YB, et al.Chemical constituents of Elephantopus scaber[J]. Chinese Herbal Medicine(中药材), 2020, 43(3): 591-595.
[30] LIU CX, CHEN SL, XIAO XH, et al.A new concept of quality marker of Chinese materia medica: quality control of Chinese medicinal products[J]. Chinese Traditional and Herbal Drugs(中草药), 2016, 47(9): 1443-1457.
[31] KUPCHAN S M, AYNEHCHI Y, CASSADY J M, et al.Isolation and structural elucidation of elephantin and elephantopin, two novel sesquiterpenoid rumor inhibitors from Elephantoupus elatus[J]. Journal of Organic Chemistry, 1969, 34: 3867-3875.
[32] Compilation Committee of Zhong Hua Ben Cao. Zhong Hua Ben Cao (中华本草)(Vol.7)[M]. Shanghai: Shanghai Science and Technology Press, 1999.
[33] GONG PY, QI J, YU BY.The Research of modern pharmacodynamic material basis based on the traditional efficacy of traditional chinese medicine is the source for original research[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology(世界科学技术-中医药现代化), 2017, 19(9): 1413-1418.
[34] XIAO K, MIAO MS.The Characteristics and the modern research of potency cold[J]. Acta Chinese Medicine(中医学报), 2013, 28(7): 1006-1008.
[35] Guangdong Food and Drug Administration. Guangdong Standard of Traditional Chinese Medicine Materials: Vol Ⅲ(广东省中药材标准:第三册)[M]. Guangzhou: Guangdong Science & Technology Press, 2019.
[36] WU J, SUN L, WANG JF, et al.Qualitative and quantitative analysis of deoxylephantopin in Elephantopus scaber L.[J]. Anhui Medical and Pharmaceutical Journal(安徽医药), 2014,10(10): 1862-1865.