Chemical Constituents of Psoralea corylifolia L.

doi:10.19803/j.1672-8629.2021.06.13

Abstract

Abstract: Objective To analyze the chemical constituents of the fruit of Psoralea corylifolia L.. Methods 95% ethanol extract of Psoralea corylifolia L. was studied with silica gel, MCI, ODS column chromatography and high performance liquid chromatography. The structure was elucidated with MS and NMR. Results Ten compounds were isolated from 95% ethanol extract of Psoralea corylifolia L.. They were seputhecarpan A (1), bakuchiol (2), 13-hydroxyisobakuchiol (3), 12-hydroxyisobakuchiol (4), bisbakuchiol A (5), bisbakuchiol B (6), bisbakuchiol C (7), 4, 2'-dihydroxy-4'-methoxy-5′-(3'', 3''-dimethylallyl)-chalkone (8), isobavachromene (9) and 4-hydroxyisolonchocarpin (10). Conclusion Compound 1 was isolated from this plant for the first time. The results of evaluation of PTP1B inhibitory activities showed that compounds 2 and 7 displayed significant PTP1B inhibitory activities.

Key words: Psoralea corylifolia L., monoterpene phenols, flavonoids, PTP1B inhibitory activity

CLC Number:

R961

GAO Hutongyue, GAO Panpan, ZANG Yingda, MA Jie, YANG Jingzhi, YE Fei, LI Chuangjun, ZHANG Dongming. Chemical Constituents of Psoralea corylifolia L.[J]. Chinese Journal of Pharmacovigilance, 2021, 18(6): 556-561.

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