Abstract: Objective To study the characteristics and regularities of combined use of Danshen Chuanxiongqin injection in the treatment of renal insufficiency in the real world. Methods The clinical data on diagnosis and treatment of patients with renal insufficiency treated with Danshen Chuanxiongqin injection between 2010 and 2019 was retrieved from the database of information systems of 18 hospitals nationwide before the tabu search algorithm was used to establish models. Community graphs or matrix methods were used to show the relationship between different self-networks in order to analyze the correlations. The core prescriptions for renal insufficiency and the correlations between multiple drugs were studied. Results The treatments of renal insufficiency with Danshen Chuanxiongqin injection included Danshen Chuanxiongqin injection combined with telmisartan to strengthen renal function, Danshen Chuanxiongqin injection combined with furosemide and spironolactone against heart failure, and Danshen Chuanxiongqin injection combined with cefodizime against infections. Conclusion Because of the complicated etiology and pathogenesis of renal insufficiency caused by various chronic diseases and improper medication, the combination with traditional Chinese medicine on the basis of conventional symptomatic treatment has a significant effect. The combined medication with Danshen Chuanxiongqin injection conforms to the guidelines for diagnosis and treatment of renal insufficiency, which provides more effective reference for individualized clinical treatment.

Key words: Danshen Chuanxiongqin injection, complex network analysis, combined use of medicine, renal insufficiency