注射用还原型谷胱甘肽致过敏性休克文献分析

doi:10.19803/j.1672-8629.2021.07.16

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (7): 674-677.
DOI: 10.19803/j.1672-8629.2021.07.16

注射用还原型谷胱甘肽致过敏性休克文献分析

郗玉玲¹, 惠红岩¹, 郭晓鹤², 邓智建^1,*

¹新乡医学院第一附属医院临床药学室,河南新乡 453100;
²新乡医学院第一附属医院消化内科,河南新乡 453100

收稿日期:2019-12-13 出版日期:2021-07-15 发布日期:2021-07-23
通讯作者: ^*邓智建,男,硕士,主任药师,临床药学。E-mail：deng710402@sina.com
作者简介:郗玉玲,女,硕士,主管药师,临床药学。
基金资助:
河南省医学科技攻关项目（201702129）; 河南省卫生厅科技攻关项目（201303107）

Literature Analysis of Anaphylactic Shock Induced by Reduced Glutathione for Injection

XI Yuling¹, HUI Hongyan¹, GUO Xiaohe², DENG Zhijian^1,*

¹Department of Clinical Pharmacy, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang Henan 453100,China;
²Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang Henan 453100, China

Received:2019-12-13 Online:2021-07-15 Published:2021-07-23

摘要/Abstract

摘要： 目的分析注射用还原型谷胱甘肽致过敏性休克的文献,探讨其致过敏性休克的规律和原因,为临床合理用药提供参考。方法检索中国知网、万方数据、维普网和Pubmed数据库,检索日期1979年1月1日至2019年9月30日,收集国内外注射用还原型谷胱甘肽导致的过敏性休克个案报道信息,统计分析病例报告中患者年龄、性别、原患疾病、药物食物过敏史、给药途径、给药剂量、用药时间、合并用药、临床表现和转归等情况。结果检索到27篇注射用还原型谷胱甘肽导致的过敏性休克病例报告,共计30例。其中20~50岁人群（58.6%）为过敏性休克发生的高危人群,男性（58.6%）高于女性（41.4%）;以速发型过敏性休克为主,即静脉滴注开始后 30 min内发生者占比最高93.9%;以呼吸系统（胸闷、呼吸困难、气喘）和循环系统（血压骤降、口唇发绀）为首发症状。结论注射用还原型谷胱甘肽可引起过敏性休克,严重者可致死亡。患者用药后 30 min内注意观察临床症状,避免严重事件发生。

关键词: 还原型谷胱甘肽, 过敏性休克, 合理用药

Abstract: Objective To explore the clinical characteristics and regularity of anaphylactic shock by caused by reduced glutathione for injection in order to provide data for clinical rational drug use. Methods Related literature published between January 1979 and September 2019 was retrieved from CNKI, Wanfang databases, VIP and Pubmed. The age, gender, daily dose, time for medication of anaphylactic shock, combined medication, preexisting diseases, clinical manifestations as well as prognosis were analyzed. Results A total of 27 case reports related to anaphylactic shock and involving 30 patients were collected. Patients with immediate anaphylactic shock (within 30 minutes of medication ) accounted for 93.9% of the total. The initial symptoms of anaphylactic shock mainly involved the respiratory system (chest tightness, dyspnea and asthma) and the circulatory system (sudden drop of blood pressure, cyanosis of the mouth and lips). Conclusion Anaphylactic shock caused by reduced glutathione for injection in severe cases can lead to fatal events, especially within 30 minutes. The symptoms of patients should be closely monitored to prevent fatal events.

Key words: reduced glutathione, anaphylactic shock, rational use of drugs

中图分类号:

R994.11

郗玉玲, 惠红岩, 郭晓鹤, 邓智建. 注射用还原型谷胱甘肽致过敏性休克文献分析[J]. 中国药物警戒, 2021, 18(7): 674-677.

XI Yuling, HUI Hongyan, GUO Xiaohe, DENG Zhijian. Literature Analysis of Anaphylactic Shock Induced by Reduced Glutathione for Injection[J]. Chinese Journal of Pharmacovigilance, 2021, 18(7): 674-677.

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注射用还原型谷胱甘肽致过敏性休克文献分析

Literature Analysis of Anaphylactic Shock Induced by Reduced Glutathione for Injection

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