基于加权TOPSIS法的贝伐珠单抗注射液药物利用评价

doi:10.19803/j.1672-8629.20230480

摘要/Abstract

摘要： 目的建立贝伐珠单抗药物利用评价标准,通过适当的药学干预措施促进贝伐珠单抗的临床合理使用。方法回顾性分析山东大学附属威海市立医院2022上半年和下半年各100份使用贝伐珠单抗注射液的住院患者归档病历,参考贝伐珠单抗说明书以及相关临床指南,制定贝伐珠单抗药物利用评价标准,利用加权优劣解距离法（TOPSIS）对贝伐珠单抗药物使用情况进行客观评价,根据评价结果分析可能原因,再制定相应的药学干预措施并给予持续干预,最后再利用加权TOPSIS法对干预后的贝伐珠单抗药物使用情况进行评价。结果药学干预前合理处方17份（17.00%）,基本合理处方0份,不合理处方83份（83.00%）;经过药学干预后合理处方55份（55.00%）,基本合理处方24份（24.00%）,不合理处方21份（21.00%）,较干预前有所改善。经过药学干预后,既往化疗方案、用药顺序、适应证、联合用药均得到改善,差异具有统计学意义（P<0.05）。结论加权TOPSIS法可以客观、全面地对贝伐珠单抗使用情况进行评价,便于发现问题并及时干预,促进其合理用药。

关键词: 贝伐珠单抗, 加权TOPSIS法, 药物利用评价, 药学干预, 处方, 合理用药, 肿瘤

Abstract: Objective To establish the drug utilization evaluation criteria for bevacizumab and promote the rational use of bevacizumab through appropriate pharmaceutical interventions. Methods The archived medical records of 100 inpatients using bevacizumab injection in the first half of 2022 and the second half of 2022 were retrospectively analyzed. According to the instructions of bevacizumab and relevant clinical guidelines, the evaluation criteria of bevacizumab drug utilization were formulated, and the weighted advantage and inferiority solution method (TOPSIS) was used to objectively evaluate the use of bevacizumab. According to the evaluation results, the possible reasons were analyzed, and then the corresponding pharmaceutical intervention measures were formulated and continuous intervention was given. Finally, the weighted TOPSIS method was used to evaluate the use of bevacizumab after intervention. Results Before pharmaceutical intervention, there were 17 reasonable prescriptions (17.00%), 0 basic reasonable prescriptions and 83 unreasonable prescriptions (83.00%). After the intervention, there were 55 reasonable prescriptions (55.00%), 24 basically reasonable prescriptions (24.00%) and 21 unreasonable prescriptions (21.00%), which was improved compared with that before the intervention. After pharmaceutical intervention, the previous chemotherapy regimen, medication sequence, indications and combination drugs were improved, and the differences were statistically significant (P<0.05). Conclusion The weighted TOPSIS method can objectively and comprehensively evaluate the use of bevacizumab, which is convenient to find problems and intervene in time and promote the reasonable use of drugs.

Key words: bevacizumab, weighted TOPSIS method, drug use evaluation, pharmaceutical interventions, prescriptions, reasonable use of drug, neoplasms

中图分类号:

R969.3

殷进军, 王淑伟, 邵姜超, 王冰. 基于加权TOPSIS法的贝伐珠单抗注射液药物利用评价[J]. 中国药物警戒, 2023, 20(12): 1421-1426.

YIN Jinjun, WANG Shuwei, SHAO Jiangchao, WANG Bing. Drug use evaluation of bevacizumab injection based on weighted TOPSIS method[J]. Chinese Journal of Pharmacovigilance, 2023, 20(12): 1421-1426.

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