中国药物警戒 ›› 2022, Vol. 19 ›› Issue (8): 889-892.
DOI: 10.19803/j.1672-8629.2022.08.14

• 安全与合理用药 • 上一篇    下一篇

唑吡坦致神经精神系统不良反应分析

庄红艳1,2, 臧彦楠1,2, 刘珊珊1,2, 牛梦溪1,2, 房萌1,2, 尹冬青1,2, 果伟1,2*   

  1. 1首都医科大学附属北京安定医院药事部,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京 100088;
    2首都医科大学人脑保护高精尖创新中心,北京 100069
  • 收稿日期:2021-03-05 出版日期:2022-08-15 发布日期:2022-08-15
  • 通讯作者: *果伟,男,副主任药师,精神专科医院药学管理。E-mail：guowe@ccmu.edu.cn
  • 作者简介:庄红艳,女,硕士,副主任药师,精神科临床药学。
  • 基金资助:
    国家自然科学基金资助项目（81873398）; 首都卫生发展科研专项资助（首发2018-4-2124）; 首都卫生发展科研专项资助（首发2018-1-2122）; 北京市中医药科技发展资金项目资助（JJ2018-42）; 北京市属医院科研培育项目（PZ2020031）; 首都卫生发展科研专项资助（首发2020-1-2031）”

Analysis of neuropsychiatric adverse reactions caused by zolpidem

ZHUANG Hongyan1,2, ZANG Yannan1,2, LIU Shanshan1,2, NIU Mengxi1,2, FANG Meng1,2, YIN Dongqing1,2, GUO Wei1,2*   

  1. 1Department of Pharmacy, Beijing Anding Hospital Affiliated to Capital Medical University, National Medical Research Center for Mental Disorders & Beijing Key Laboratory for Diagnosis and Treatment of Mental Disorders, Beijing 100088, China;
    2Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China
  • Received:2021-03-05 Online:2022-08-15 Published:2022-08-15

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摘要： 目的 通过分析唑吡坦致神经精神系统的药品不良反应（ADR）报告,探讨ADR的特点和规律,为临床合理使用新型催眠药物提供依据。方法 选取并分析2004年1月1日至2021年12月31日我院上报的6例唑吡坦致神经精神系统ADR的病例,对患者的药物治疗情况、ADR情况、治疗措施及转归等进行分析,探讨唑吡坦导致神经精神系统ADR的特点。结果 6例患者均为女性。患者服用唑吡坦后,患者多在较短时间内出现ADR。多数患者服药当晚即出现ADR、仅1例遗忘ADR发生在服药后第5天。ADR的临床表现方面,包括次日清晨不能回忆夜间的反常行为,意识不清楚等。患者出现ADR后,停药并换用其他镇静催眠药等处理后,症状均缓解或恢复正常。结论 唑吡坦所致神经精神系统ADR中,谵妄及可疑谵妄占比较大。在正常日剂量使用时仍有发生ADR的可能。服用唑吡坦后,女性可能更容易出现神经精神系统ADR,在治疗初期,尤其是服药当晚,应密切观察ADR发生情况。临床应用过程中应严格把握药品适应证,保障用药安全。

关键词: 唑吡坦, 神经系统, 精神系统, 药品不良反应, 合理用药

Abstract: Objective To analyze the reports of adverse drug reactions(ADR) in the neuropsychiatric system caused by zolpidem, and explore the characteristics and patterns of adverse reactions, and to promote rational use of new hypnotic drugs in clinical practice. Methods Six cases of neuropsychiatric ADR caused by zolpidem reported in our hospital from January 1, 2004 to December 31, 2021 were selected and analyzed. Medications, ADR, treatments and outcomes of the patients were analyzed. The characteristics of neuropsychiatric ADR caused by zolpidem were studied. Results All the six patients were female. Most of the patients had adverse reactions soon after taking zolpidem. ADR occurred on the very night this drug was taken in most patients, and only one case of amnesia occurred on the 5th day after taking the drug. The clinical manifestations of adverse reactions included the inability to recall the abnormal behavior of the previous night and unclear consciousness. After the onset of adverse reactions, the patients discontinued this drug and shifted to other sedative and hypnotic drugs, and the symptoms were relieved or returned to normal. Conclusion ADR of the nervous system caused by zolpidem, delirium and suspected delirium make up a large proportion. There are still the chances of adverse reactions at normal daily doses. Women may be more prone to neuropsychiatric ADR after taking zolpidem, and adverse reactions should be closely monitored at the beginning of treatment, especially on the night of treatment. The indications of drugs should be kept in mind in clinical practice to ensure the safety of drug use.

Key words: zolpidem, the nervous system (CNS), the mental system, adverse drug reaction(ADR), rational use of drugs

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