基于文献分析的老年人中成药合理用药与药学服务思考

doi:10.19803/j.1672-8629.2022.06.03

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (6): 595-599.
DOI: 10.19803/j.1672-8629.2022.06.03

• 特殊人群的中药药物警戒与药学服务专栏 • 上一篇下一篇

基于文献分析的老年人中成药合理用药与药学服务思考

马冰冰¹, 张晓朦^1,2, 张冰^1,2,*, 林志健^1,2, 吕锦涛^1,2

¹北京中医药大学中药学院,北京 102488;
²北京中医药大学中药药物警戒与合理用药研究中心,北京 102488

收稿日期:2022-02-07 出版日期:2022-06-15 发布日期:2022-06-13
通讯作者: ^* 张冰,女,博士,教授·博导,主任医师,中药药物警戒与合理用药研究、中药药性理论与名老中医传承研究、中药防治代谢性疾病研究。E-mail：zhangbing6@263.net
作者简介:马冰冰,女,在读硕士,中药药物警戒与合理用药研究。
基金资助:
国家中医药管理局-国家中医药领军人才支持计划“岐黄学者”项目; 中国毒理学会临床毒理专项课题（CST2020CT501）; 国家自然科学基金资助项目（81874349）

Consideration of rational use of traditional Chinese medicine and pharmaceutical services for the elderly based on literature analysis

MA Bingbing¹, ZHANG Xiaomeng^1,2, ZHANG Bing^1,2,*, LIN Zhijian^1,2, LYU Jintao^1,2

¹School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China;
²Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China

Received:2022-02-07 Online:2022-06-15 Published:2022-06-13

摘要/Abstract

摘要： 目的挖掘老年人应用中成药导致药品不良反应/事件（adverse drug reaction/event, ADR/ADE）的因素,提出针对性的合理用药依据与药学服务建议。方法以《国家基本药品目录》（2018版）中收载的268个品种中成药为检索对象,系统检索中国知网、万方数据、维普网中文文献数据库等发表的中成药致老年人ADR/ADE个案报道。时间截至2021年1月1日相关文献。经因果关系判断,采用类神经网络方法挖掘老年人用药发生ADR/ADE的影响因素。挖掘传统古籍有关老年人合理用药的相关表述,形成合理用药与药学服务思考。结果共收集老年人应用中成药的ADR/ADE个案373例,涉及中成药88种,累及全身性损害、皮肤及附件系统损害等。ADR/ADE严重程度与用药疗程、给药方式、联合用药情况等存在较强的关联关系。梳理古籍中有关老年人警戒信息20 459条,涉及用药禁忌、治疗原则、用药剂量、服药方法等方面。结论临床需关注老年人自行用药、联合用药、超剂量超疗程等情况,加强药学服务,提升合理用药水平。

关键词: 中成药, 老年人, 药品不良反应, 药物警戒, 药学服务, 合理用药

Abstract: Objective The factors of adverse drug reactions/events(ADR/ADE) caused by the use of proprietary Chinese medicines in the elderly and the rational drug use basis and pharmaceutical service suggestions. Methods Taking 268 varieties of Chinese patent medicines contained in the national catalogue of essential drugs (2018 Edition) as the search object, the case reports of ADR/ADE caused by Chinese patent medicines to the elderly published in Chinese journal databases such as CNKI, Wanfang Data and VIP database were systematically searched. The time is up to January 1, 2021. After judging the causal relationship, the neural network method was used to mine the influencing factors of ADR/ADE in the elderly. Excavate the relevant expressions about rational drug use of the elderly in traditional ancient books, and form the thinking of rational drug use and pharmaceutical services. Results A total of 373 cases of ADR/ADE using Chinese patent medicines in the elderly were collected, involving 88 kinds of Chinese patent medicines, involving systemic damage, skin and adnexal system damage. There was a strong correlation between the severity of ADR/ADE and the duration of medication, mode of administration, and combination medication. A total of 20 459 pieces of warning information about the elderly in ancient books were sorted out, involving drug contraindications, treatment principles, drug dosage, and drug administration methods. Conclusion Clinical attention should be paid to the elderly's self-medication, combined medication, overdose and ultra-course of treatment, etc., strengthen pharmaceutical services, and improve the level of rational drug use.

Key words: Chinese patent medicine, the elderly, adverse drug reactions, pharmacovigilance, pharmaceutical services, rational drug use

中图分类号:

马冰冰, 张晓朦, 张冰, 林志健, 吕锦涛. 基于文献分析的老年人中成药合理用药与药学服务思考[J]. 中国药物警戒, 2022, 19(6): 595-599.

MA Bingbing, ZHANG Xiaomeng, ZHANG Bing, LIN Zhijian, LYU Jintao. Consideration of rational use of traditional Chinese medicine and pharmaceutical services for the elderly based on literature analysis[J]. Chinese Journal of Pharmacovigilance, 2022, 19(6): 595-599.

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基于文献分析的老年人中成药合理用药与药学服务思考

Consideration of rational use of traditional Chinese medicine and pharmaceutical services for the elderly based on literature analysis

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