中国药物警戒 ›› 2024, Vol. 21 ›› Issue (1): 102-106.
DOI: 10.19803/j.1672-8629.20230443

• 安全与合理用药 • 上一篇    下一篇

694例癫痫医师药师联合门诊患者药品不良反应分析

蒋文硕1, 杨莉2,*   

  1. 1首都医科大学第五临床医学院临床药学系,北京 100069;
    2首都医科大学附属北京天坛医院药学部,北京 100070
  • 收稿日期:2023-07-14 出版日期:2024-01-15 发布日期:2024-01-18
  • 通讯作者: *杨莉,女,硕士,副主任药师,临床药学与药事管理。E-mail：0530yangli@163.com
  • 作者简介:蒋文硕,女,本科,临床药学。
  • 基金资助:
    国家重点研发计划（2020YFC2008305）

Adverse drug reaction among 694 patients in an epilepsy physician-pharmacist joint clinic

JIANG Wenshuo1, YANG Li2,*   

  1. 1Department of Clinical Pharmacy, The Fifth Clinical Medical College of Capital Medical University, Beijing 100069, China;
    2Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2023-07-14 Online:2024-01-15 Published:2024-01-18

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摘要： 目的 分析癫痫医师药师联合门诊患者药品不良反应（ADR）发生率、常见类型及其相关因素,为癫痫个体化治疗提供依据。方法 回顾性调查2020年1月1日至2021年12月31日于某院癫痫医师药师联合门诊就诊的患者,对患者性别、年龄及ADR发生情况进行描述性统计,并对患者ADR发生率与性别、年龄、是否联合用药的相关性进行卡方检验。结果 694例癫痫医师药师联合门诊患者中ADR发生率为36.17%（251/694）。男性和女性患者ADR发生率分别为37.08%（142/383）、35.05%（109/311）,两者比较无统计学差异（χ2=0.306,P=0.580）。≤14岁、15~44岁、45~64岁、≥65岁年龄组的ADR发生率分别为24.00%、33.88%、42.96%、55.10%;4个年龄组的ADR发生率之间有统计学差异（χ2=16.226,P=0.001）。合并用药与无合并用药的ADR发生率分别为45.00%和26.65%,两者比较有统计学差异（χ2=25.279,P=0.000）。结论 癫痫的药物治疗强调个体化,应当在充分考虑患者性别、年龄、合并用药等基础上制定给药方案,必须向患者或家属强调定期复查的重要性与复查项目,保障用药安全。

关键词: 癫痫, 医师, 药师, 联合门诊, 抗癫痫药, 药品不良反应, 个体化治疗

Abstract: Objective To analyze the incidence,dominating types and related factors of adverse drug reaction (ADR) in patients at an epilepsy physician-pharmacist joint clinic and to provide evidence for individualized treatment of epilepsy. Methods A retrospective survey was conducted among patients who visited the epilepsy physician-pharmacist joint clinic in our hospital in 2020-2021. The gender and age of these patients and incidence of adverse reactions were statistically analyzed before Chi-square tests were performed on the correlations between the incidence of ADR and gender, age and combined medications. Results The incidence of ADR averaged 36.17% (251/694), which was 37.08% among male patients (142/383) and 35.05% among female ones (109/311), so the difference was of no statistical difference (χ 2=0.306, P=0.580). The incidence of ADR was 24.00%, 33.88%, 42.96%, and 55.10% respectively in the group aged 14 or older, in the group ages 15 to 44, in the group aged 45-64 and in the group aged 65 and older, so the difference was statistically significant (χ 2=16.226, P=0.001). The incidence of ADR in patients treated with combinations of drugs and those without was 45.00% and 26.65%, respectively, and the difference was of statistical significance (χ 2=25.279, P=0.000). Conclusion Medications for epilepsy should be individualized based on the gender, age, and combination of drugs. Patients or their family members should be reminded of the importance of regular re-examination to ensure the safety of medication.

Key words: epilepsy, physician, pharmacist, joint clinic, antiepileptic drugs, adverse drug reactions, individualized treatment

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