克拉霉素致急性短暂性抑郁症不良反应1例分析

doi:10.19803/j.1672-8629.20230698

中国药物警戒 ›› 2024, Vol. 21 ›› Issue (3): 352-354.
DOI: 10.19803/j.1672-8629.20230698

克拉霉素致急性短暂性抑郁症不良反应1例分析

杨雪婷¹, 何波², 闫鸿丽³, 李冬梅⁴

¹云南省第一人民医院,昆明理工大学附属医院药学部,云南昆明 650032;
²昆明医科大学药学院,云南省天然药物药理重点实验室,云南昆明 650500;
³云南中医药大学药剂教研室,云南昆明650500;
⁴临沧市人民医院药剂科,云南临沧 677000

收稿日期:2023-11-07 出版日期:2024-03-15 发布日期:2024-03-18
通讯作者: ^*李冬梅,女,本科,主管药师,医院药学。E-mail：528415180@qq.com
作者简介:杨雪婷,女,硕士,副主任药师,临床药学。
基金资助:
国家自然科学基金资助项目（81860665）; 云南省科技厅科技计划项目（202101AZ070001 - 036）; 云南省第一人民医院临床医学研究中心开放项目（2023YJZX-YX24）

One case of acute transient depression caused by clarithromycin

YANG Xueting¹, HE Bo², YAN Hongli³, LI Dongmei⁴

¹Department of Pharmacy, the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming Yunnan 650032, China;
²School of Pharmaceutical Sciences, Kunming Medical University, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Yunnan 650500, China;
³Teaching and Resarch Office of Pharmacy, Yunnan University of Chinese Medicine, Kunming Yunnan 650500, China;
⁴Department of Pharmacy, Lincang People’s Hospital, Lincang Yunnan 677000, China;

Received:2023-11-07 Online:2024-03-15 Published:2024-03-18

摘要/Abstract

摘要： 目的分析使用克拉霉素致急性短暂性抑郁的不良反应,为临床使用提出预警并及早处置提供参考。方法对1例29岁女性患者应用四联方案(阿莫西林、克拉霉素、泮托拉唑、枸橼酸铋钾)根治幽门螺杆菌感染引起急性短暂性抑郁症进行分析。结果考虑是四联抗幽门螺杆菌感染药物导致的急性短暂性抑郁症,循证学证据表明克拉霉素可能是最易引起急性短暂性抑郁的药物。结论在使用根治幽门螺杆菌感染药物时,医务人员需密切关注患者的情绪变化,若发生急性短暂性抑郁症及时停药,防止患者症状进一步加重。

关键词: 克拉霉素, 阿莫西林, 泮托拉唑, 枸橼酸铋钾, 幽门螺杆菌, 抑郁症, 药品不良反应

Abstract: Objective To analyze the adverse reactions-acute transient depression-caused by a quadruple anti-Helicobacter pylori regimen, and to provide reference for early detection and prompt clinical interventions in such cases. Methods Analysis was made of the clinical data on a 29-year-old female patient who underwent a quadruple regimen (amoxicillin, clarithromycin, pantoprazole, and bismuth potassium citrate) because of acute transient depression caused by Helicobacter pylori infection. Results The transient acute depression was considered to have been triggered by the combined use of four anti-Helicobacter pylori drugs. Evidence-based medicine suggested that clarithromycin was the drug most likely to induce acute transient depression. Conclusion Healthcare providers should vigilantly observe patients for emotional fluctuations during the administration of pharmaceutical interventions for the complete eradication of H. pylori infection. In the event of acute transient depression, it is imperative to promptly discontinue the medication to forestall the worsening of symptoms.

Key words: clarithromycin, amoxicillin, pantoprazole, bismuth potassium citrate, helicobacter pylori, depression, adverse drug reactions

中图分类号:

R975
R994.1

杨雪婷, 何波, 闫鸿丽, 李冬梅. 克拉霉素致急性短暂性抑郁症不良反应1例分析[J]. 中国药物警戒, 2024, 21(3): 352-354.

YANG Xueting, HE Bo, YAN Hongli, LI Dongmei. One case of acute transient depression caused by clarithromycin[J]. Chinese Journal of Pharmacovigilance, 2024, 21(3): 352-354.

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克拉霉素致急性短暂性抑郁症不良反应1例分析

One case of acute transient depression caused by clarithromycin

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