注射用奥美拉唑钠致低钠血症1例分析

doi:10.19803/j.1672-8629.20230716

中国药物警戒 ›› 2024, Vol. 21 ›› Issue (4): 461-463.
DOI: 10.19803/j.1672-8629.20230716

注射用奥美拉唑钠致低钠血症1例分析

李少强, 孔旭东, 李朋梅^*

中日友好医院药学部,北京 100029

收稿日期:2023-11-14 出版日期:2024-04-15 发布日期:2024-04-18
通讯作者: ^*李朋梅,女,硕士,副主任药师,医院药学。E-mail：lipengmei@yeah.net
作者简介:李少强,男,硕士,药师,临床药学。
基金资助:
国家重点研发计划（2020YFC2005504）

One case of hyponatremia caused by omeprazole sodium for injection

LI Shaoqiang, KONG Xudong, LI Pengmei^*

Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China

Received:2023-11-14 Online:2024-04-15 Published:2024-04-18

摘要/Abstract

摘要： 目的分析注射用奥美拉唑钠致低钠血症不良反应及其代谢基因型和与三唑类抗真菌药相互作用,为临床安全使用质子泵抑制剂提供参考。方法报道1例80岁感染侵袭性肺曲霉菌病患者,分析其用药后致低钠血症原因。结果患者CYP2C19慢代谢型且联合三唑类抗真菌药物,低钠血症可能与注射用奥美拉唑钠有关,怀疑为注射用奥美拉唑钠导致的不良反应。结论临床发现难治性低钠血症时需考虑质子泵抑制剂引起的可能性。对于CYP2C19慢代谢型患者,质子泵抑制剂与肝药酶抑制剂应谨慎合并使用。

关键词: 奥美拉唑, 注射, 伏立康唑, 艾沙康唑, 低钠血症, 质子泵抑制剂, 药品不良反应

Abstract: Objective To analyze one case of hyponatremia caused by omeprazole sodium for injection and its metabolic genotypes with triazole antifungals so as to provide reference for safe use of proton pump inhibitors. Methods The clinical data of an 80-year-old patient with invasive pulmonary aspergillosis was analyzed, and the cause of hyponatremia was investigated. Results The patient's hyponatremia might have been related to omeprazole, an adverse reaction caused by omeprazole sodium. Conclusion The possibility of adverse reactions being caused by proton pump inhibitors should be considered when dealing with refractory hyponatremia in clinical practice. When a patient with slow metabolism for CYP2C19 uses hepatic enzyme inhibitors, proton pump inhibitors should be used with caution.

Key words: omeprazole, injection, voriconazole, isavuconazonium, hyponatremia, proton pump inhibitors, adverse drug reactions

中图分类号:

李少强, 孔旭东, 李朋梅. 注射用奥美拉唑钠致低钠血症1例分析[J]. 中国药物警戒, 2024, 21(4): 461-463.

LI Shaoqiang, KONG Xudong, LI Pengmei. One case of hyponatremia caused by omeprazole sodium for injection[J]. Chinese Journal of Pharmacovigilance, 2024, 21(4): 461-463.

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注射用奥美拉唑钠致低钠血症1例分析

One case of hyponatremia caused by omeprazole sodium for injection

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