基于物质基础探析十八反中“藻戟遂芫俱战草”配伍禁忌

doi:10.19803/j.1672-8629.20230324

摘要/Abstract

摘要： 目的基于物质基础探析十八反中“藻戟遂芫俱战草”配伍禁忌, 为完善中药配伍禁忌理论和指导临床应用提供依据。方法通过检索近年来国内外文献, 从物质基础角度分析“藻戟遂芫俱战草”甘草组反药组合配伍前后物质基础变化和其对毒效作用的影响。结果海藻、大戟、甘遂、芫花与甘草配伍对反药组合的毒、效成分溶出有影响, 配伍后, 可能通过促进毒性成分溶出、抑制毒性成分代谢、抑制有效成分溶出、产生新的物质、破坏物质结构等途径产生增毒减效的“毒”或增效减毒的“效”作用。结论甘草组反药组合并非绝对的配伍禁忌, 还需继续基于物质基础, 结合药物毒理基因组学和代谢组学等方法及高效技术进行研究。

关键词: 十八反, 海藻, 大戟, 甘遂, 芫花, 甘草, 物质基础, 配伍禁忌, 毒效作用

Abstract: Objective By study on the the material basis and mechanism on glycyrrhiza co-administered with sargassum pallidum, euphorbia pekinensis, euphorbia kansui and daphne genkwa, so as to provide a basis for improving the theory of incompatibility of TCM and guide the use of incompatible combinations. Methods In this paper, we analyzed the changes of the material basis before and after the combination and the effects on the toxicity of incompatible combinations in the Glycyrrhiza group of “zao ji sui yuan ju zhan cao” from the perspective of material basis by searching the domestic and foreign literature in recent years. Results The compatibility of Haizao (Sargassum), Jingdaji (Euphorbiae Pekinensis Radix), Gansui (Kansui Radix), Yuanhua (Genkwa Flos) and Gancao (Glycyrrhizae Radix Et Rhizoma) had an effect on the dissolution of toxic and effective components of incompatible combinations. After the compatibility, it may play a “toxic” or “effective” effect by promoting the release of toxic components, inhibiting the metabolism of toxic components, inhibiting the dissolution of effective components, producing new substances, and destroying the structure of substances, etc. Conclusion The opposing herbal remedies combination of the Glycyrrhiza group is not an absolute incompatibility, and it is necessary to continue to study based on the material base, combined with relevant drug toxicogenomics and metabolomics and other methods, as well as efficient technologies.

Key words: eighteen incompatible medicaments, sargassum pallidum, euphorbia pekinensis, euphorbia kansui, daphne genkwa, glycyrrhiza, material basis, incompatibility, toxic or effective effect

中图分类号:

R994.1

安卓佳, 张可怡, 周密迦, 黄礼杰, 修琳琳. 基于物质基础探析十八反中“藻戟遂芫俱战草”配伍禁忌[J]. 中国药物警戒, 2023, 20(12): 1435-1440.

AN Zhuojia, ZHANG Keyi, ZHOU Mijia, HUANG Lijie, XIU Linlin. Study on the material basis and mechanism on glycyrrhiza co-administered with sargassum pallidum, euphorbia pekinensis, euphorbia kansui and daphne genkwa incompatibility[J]. Chinese Journal of Pharmacovigilance, 2023, 20(12): 1435-1440.

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