常见有毒药材的毒性差异分析

doi:10.19803/j.1672-8629.2022.04.02

摘要/Abstract

摘要： 目的将收集的206种有毒药材的毒性研究现状进行归纳总结,为合理利用和深入开发有毒药材提供科学依据。方法梳理有毒药材名录,检索中国知网、维普网、万方数据、中国生物医学文献数据、PubMed建库至2021年9月20日已报道的药材毒性的文献,并分析归纳。结果在206种有毒药材中,109种有毒性研究的报道,主要有肾毒性、肝毒性、心血管毒性等。结论大部分有毒药材的毒性成分和毒性机制尚不清楚,需加大研究力度,以保证其临床使用更安全有效。

关键词: 有毒药材, 毒性, 差异分析

Abstract: Objective To summarize the toxicity of 206 kinds of toxic medicinal materials, so as to provide scientific basis for rational utilization and in-depth development of them. Methods The list of toxic medicinal materials, search the literature on from the establishment to september 20, 2021 toxic medicinal materials reported by CNKI, VIP, Wanfang data, Chinese biomedical literature data and PubMed from the establishment to September 20, 2021 was analyzed and summarized. Results Among 206 kinds of toxic medicinal materials, the toxicity about 109 kinds were researched, including renal toxicity, hepatotoxicity and cardiovascular toxicity. Conclusion The toxic components and toxic mechanism of most toxic medicinal materials are still unknown, and more research to do for their safe and effective clinical use.

Key words: toxic medicinal materials, toxicity, differences analysis

中图分类号:

R931R994

白贞芳, 王宁, 吴菲, 肖瑶, 姜丹, 任广喜, 刘春生. 常见有毒药材的毒性差异分析[J]. 中国药物警戒, 2022, 19(4): 353-356.

BAI Zhenfang, WANG Ning, WU Fei, XIAO Yao, JIANG Dan, REN Guangxi, LIU Chunsheng. Toxicity differences analysis of toxic medicinal materials[J]. Chinese Journal of Pharmacovigilance, 2022, 19(4): 353-356.

参考文献

[1] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People's Republic of China(中华人民共和国药典)[S]. Beijing: China Medical Science and Technology Press, 2020.
[2] Compilation group of national collection of Chinese herbal medicines. National compilation of Chinese herbal medicine(全国中草药汇编)[M]. Beijing: People's Health Publishing House, 2014.
[3] ZHANG W, REN K, REN SM, et al.UPLC-Q-Exactive-MS analysis for hepatotoxicity components of Evodiae Fructus based on spectrum-toxicity relationship[J]. Journal of Chromatography B, 2021, 1176: 122772.
[4] WU CT, WANG X, XU M, et al.Intracellular accumulation as an indicator of cytotoxicity to screen hepatotoxic components of chelidonium majus L. by LC-MS/MS[J]. Molecules, 2019, 24(13): 2410.
[5] FENG Q, YAO JC, LI X, et al.Network analysis and mechanism prediction of cardiotoxicity caused by alkaloids from Radix Aconiti[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2022, 19(1): 62-68.
[6] ZHAO DS, WU ZT, LI ZQ, et al.Liver-specific metabolomics characterizes the hepatotoxicity of Dioscorea bulbifera rhizome in rats by integration of GC-MS and 1 H-NMR[J]. Journal of Ethnopharmacology, 2018, 226:111-119.
[7] YUAN ZQ, YUAN ZH, MUHAMMAD H, et al.A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein[J]. Acta Pharmaceutica Sinica B, 2020, 10(5): 861-877.
[8] MOREIRA R, PEREIRA DM, VALENTAO P, et al.Pyrrolizidine alkaloids: chemistry, pharmacology, toxicology and food safety[J]. International Journal of Molecular Sciences, 2018, 19(6): 1688.
[9] SUN XX, XIANG E, QIU SK, et al.Research progress on toxicity of pyrrolizidine alkaloids[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(2): 76.
[10] HABS M, BINDER K, KRAUSS S, et al.A balanced risk-benefit analysis to determine human risks associated with pyrrolizidine alkaloids(PA)-the case of herbal medicinal products containing St. John's wort extracts (SJW)[J]. Nutrients, 2017, 9(7): 717.
[11] YANG M, RUAN J, FU PP, et al.Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity[J]. Chem Biol Interact, 2016, 243: 119-126.
[12] ZHAO FH, HOU XT, HAO EW, et al.Chemical constituents,toxicology and pharmacological effect of momordicae semen[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2020, 26(3): 222-235.
[13] YU HL, WANG W, WU H, et al.Effect of processing on lectin protein of four toxic traditional Chinese medicines of Araceae[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2019, 44(24): 5398-5404.
[14] ZHENG K, ZHONG XF, ZHANG H.Advances in research on constituents and pharmacological effects of Artemisia Argyi essential oil[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2020, 26(18): 224-234.
[15] MA HY, WU JJ, GE GB, et al.Research progress on metabolism and toxicity of aristolochic acid in vivo[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology(世界科学技术-中医药现代化), 2019, 21(2): 182-189.
[16] LIU L, YU HL, WANG KL, et al.Effects of toxic fractions of Euphorbiae Ebracteolatae Radix on toxicity of mice intestinal tract and colon aquaporins expression level before and after vinegar processing[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2018, 43(12): 2516-2521.
[17] ZHANG ZT, JIAN XX, DING JY, et al.Further studies on structure-cardiac activity relationships of diterpenoid alkaloids[J]. Natural Product Communications, 2015, 10(12): 2075-2084.
[18] TANG CH, XIAO X, DUAN HZ, et al.Research progress on the mechanism of aconitine induced central neurotoxicity[J]. Guangxi Medical Journal(广西医学), 2018, 40(20): 2448-2451.
[19] ZHAO Y, BU Q, ZHOU Y, et al.Mechanism study of Aconitum induced neurotoxicity in PC12 cells: involvement of dopamine release and oxidative damage[J]. Neurotoxicology, 2010, 31(6): 752-757.
[20] WANG L.Central neurotoxicity of aconitine and intervention of Shuanghuanglian[D]. Wengzhou: Wenzhou Medical University, 2014.
[21] LI TF, GONG N, WANG YX.Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: involvement of spinal microglial dynorphin expression and implications for aconitum processing[J]. Frontiers in Pharmacology, 2016, 7: 367.
[22] WANG L, ZHAO GJ, LI MF, et al.Brain injury mechanism of acute aconitine poisoning and the intervention effect of Baicalin[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care(中国中西医结合急救杂志), 2014, 21(4): 289-293.
[23] LI LP, TU MJ, YANG X, et al.The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity[J]. Drug Metabolism and Disposition, 2014, 42(7): 1227-1234.
[24] CHEN SP, YANG L, FENG J.Nitidine chloride inhibits proliferation and induces apoptosis in ovarian cancer cells by activating the Fas signalling pathway[J]. International Journal of Pharmaceutics, 2018, 70(6): 778-786.
[25] LIU LM, XIONG DD, LIN P, et al.DNA topoisomerase 1 and 2 A function as oncogenes in liver cancer and may be direct targets of nitidine chloride[J]. Journal of Thoracic Oncology, 2018, 53(5): 1897-1912.
[26] LI C, CHEN YC, ZENG QQ, et al.Accumulation of nitidine chloride in rat heart and its mechanism[J]. Acta Pharmaceutica Sinica(药学学报), 2019, 54(5): 913-918.
[27] ZAN K, ZHANG R, LI YL, et al.Research progress of quality control of pyrrolizidine alkaloids in Farfarae Flos[J]. Chinese Journal of Pharmaceutical Analysis(药物分析杂志), 2021, 41(5): 753-759.
[28] REN LW, ZHENG XJ, LI W, et al.Historical cognition and evaluation of Tripterygium Wilfordii toxicity[J]. Herald of Medicine(医药导报), 2021, 40(5): 637-641.
[29] MENG TQ, MA HB.Research progress on reproductive toxicity mechanism of Tripterygium wilfordii[J]. Chinese Archives of Traditional Chinese Medicine(中华中医药学刊), 2020, 38(3): 196-198.
[30] ZHAO YT, WU SP, HU CL, et al.Reviews on chemical compositions and pharmacological effect of gelsemium elegans[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2019, 25(3): 200-210.
[31] SUN MX, XU QQ, MENG WQ, et al.Research progress on pharmacological and toxicological mechanism of Gelsemium elegans[J]. Journal of Toxicology(毒理学杂志), 2020, 34(4): 336-341.
[32] SHUKLA B, SAXENA S, USMANI S, et al.Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review[J]. Clinical Phytoscience, 2021, 7(1): 34.
[33] CHEN SF, ZHAO XP, YU SM, et al.Study on acute toxicity of Yao medicine baihuadan before and after processing[J]. Journal of Medicine & Pharmacy of Chinese Minorities(中国民族医药杂志), 2017, 23(2): 65-66.
[34] WANG JM, WU XH, LIU C, et al.Study on toxicity, compatibility and processing of Huangyaozi[J]. Lishizhen Medicine and Materia Medica Research(时珍国医国药), 2019, 30(10): 2480-2482.