瞬时受体电位通道在病毒性肺炎发展过程中的关键作用

doi:10.19803/j.1672-8629.20230618

中国药物警戒 ›› 2024, Vol. 21 ›› Issue (2): 137-140.
DOI: 10.19803/j.1672-8629.20230618

• 基于多模型、多靶点的中药抗感染药效及机制研究专栏（一） • 上一篇下一篇

瞬时受体电位通道在病毒性肺炎发展过程中的关键作用

包蕾¹, 耿子涵¹, 李舒冉¹, 冀祖恩^2,3, 赵荣华¹, 孙静¹, 郭姗姗^1,*, 崔晓兰^1#

¹中国中医科学院中药研究所生物安全试验室,北京 100700;
²新疆甘草及制品研究重点实验室,新疆库尔勒 841011;
³新疆全安药业股份有限公司,新疆库尔勒 841011

收稿日期:2023-09-28 出版日期:2024-02-15 发布日期:2024-02-06
通讯作者: ^*郭姗姗,女,博士,研究员,中药抗病毒及抗感染药理。E-mail: ssguo@icmm.ac.cn. ^#为共同通信作者。
作者简介:包蕾,女,硕士,中药药理。
基金资助:
国家自然科学基金资助项目（82141206）

The critical role of TRP channels in the progression of viral pneumonia

BAO Lei¹, GENG Zihan¹, LI Shuran¹, JI Zuen^2,3, ZHAO Ronghua¹, SUN Jing¹, GUO Shanshan^1,*, CUI Xiaolan^1#

¹Biosecurity Laboratory, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
²Xinjiang Key Laboratory for Reserch of Licorice and Products, Korla Xinjiang 841011, China;
³Xinjiang Quanan Pharmaceutical Co., Ltd., Korla Xinjiang 841011, China

Received:2023-09-28 Online:2024-02-15 Published:2024-02-06

摘要/Abstract

摘要： 目的对病毒性肺炎感染过程中与瞬时受体电位（transient receptor potential,TRP）通道家族可能的发生机制进行综述研究。方法通过检索中国知网和PubMed数据库,收集近30年关于TRP通道家族与病毒性肺炎关系研究和机制探讨的相关报道。结果作为细胞膜上的离子受体通道,TRP通道能够调节细胞内外钙离子平衡,抑制或加速病毒入侵宿主;通过加速钙离子内流,激化细胞氧化应激反应,加速细胞自噬或凋亡;通过促进细胞形态变化,增强其对炎症介质和细胞因子的响应等。结论 TRP通道是病毒感染宿主过程中的重要调控因子,其对病毒感染过程中的多个生理过程产生直接或间接的影响,进一步对TRP通道家族进行深入研究,可成为抗病毒药物研发的新靶点,为临床抗病毒性肺炎提供新思路。

关键词: 肺炎, 病毒性肺炎, 瞬时受体电位通道, 离子, 细胞

Abstract: Objective To conduct a comprehensive review of the potential mechanisms of occurrence between viral pneumonia infection and the TRP channel family. Methods By searching CNKI and PubMed, the reports from the past 30 years on the relationship between the TRP channel family and viral pneumonia, as well were as discussions the underlying mechanisms were discussed. Results As ion receptor channels on the cell membrane, TRP channels can regulate the balance of calcium ions inside and outside the cell, inhibiting or accelerating virus invasion into the host. By accelerating the influx of calcium ions, they intensify cellular oxidative stress responses, speeding up cell autophagy or apoptosis. Additionally, by promoting changes in cell morphology, they enhance the cell’s response to inflammatory mediators and cytokines. Conclusion TRP channels are crucial regulatory factors in the process of viral infection of hosts, exerting direct or indirect effects on various physiological processes during the infection. Therefore, a deeper study of the TRP channel family can offer new targets for antiviral drug development, providing fresh perspectives for clinical treatment of viral pneumonia.

Key words: pneumonia, viral pneumonia, transient receptor potential channels, ion, cell

中图分类号:

包蕾, 耿子涵, 李舒冉, 冀祖恩, 赵荣华, 孙静, 郭姗姗, 崔晓兰. 瞬时受体电位通道在病毒性肺炎发展过程中的关键作用[J]. 中国药物警戒, 2024, 21(2): 137-140.

BAO Lei, GENG Zihan, LI Shuran, JI Zuen, ZHAO Ronghua, SUN Jing, GUO Shanshan, CUI Xiaolan. The critical role of TRP channels in the progression of viral pneumonia[J]. Chinese Journal of Pharmacovigilance, 2024, 21(2): 137-140.

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瞬时受体电位通道在病毒性肺炎发展过程中的关键作用

The critical role of TRP channels in the progression of viral pneumonia

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