药源性心脏毒性研究进展

doi:10.19803/j.1672-8629.20230293

摘要/Abstract

摘要： 药源性心脏毒性是由药物引发的严重不良反应之一,其严重程度从轻微的心电图改变到致命性心律失常不等。药源性心脏毒性具有多源性、高发性、隐匿性、特殊人群易发性、临床表现多样性,机制复杂性等临床特点。近年来,随着药物的广泛应用,药源性心脏毒性的研究备受关注。本文将从药源性心脏毒性的临床表现、发生机制及预防措施等方面综述其研究进展,以期为临床防范药源性心脏毒性提供参考。

关键词: 药源性, 心脏毒性, 心律失常, 临床表现, 临床特点, 机制, 预防指施

Abstract: Pharmacogenic cardiotoxicity is one of the severe adverse reactions triggered by drugs, the severity of which ranges from mild electrocardiographic changes to fatal arrhythmias. Pharmacogenic cardiotoxicity is characterized by multiple sources, high incidence, insidiousness, susceptibility to special populations, diversity of clinical manifestations, and complexity of mechanisms. In recent years, research on pharmacogenic cardiotoxicity has received much attention. This paper reviews the research progress in pharmacogenic cardiotoxicity in terms of its clinical manifestations, mechanisms of occurrence and preventive measures to provide reference for clinical prevention of pharmacogenic cardiotoxicity.

Key words: pharmacogenic, cardiotoxicity, arrhythmias, clinical manifestations, clinical characteristic, mechanisms, preventive measures

中图分类号:

R994.11

张冰, 萨日娜, 张晓朦, 张丹, 林志健, 王雨. 药源性心脏毒性研究进展[J]. 中国药物警戒, 2023, 20(8): 841-847.

ZHANG Bing, SA Rina, ZHANG Xiaomeng, ZHANG Dan, LIN Zhijian, WANG Yu. Research progress in pharmacogenic cardiotoxicity[J]. Chinese Journal of Pharmacovigilance, 2023, 20(8): 841-847.

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