倾向性评分探索真实世界中连花清瘟胶囊（颗粒）治疗肺部感染的疗效评价

doi:10.19803/j.1672-8629.2022.02.03

中国药物警戒 ›› 2022, Vol. 19 ›› Issue (2): 126-129.
DOI: 10.19803/j.1672-8629.2022.02.03

• 真实世界中成药用药方案研究专栏 • 上一篇下一篇

倾向性评分探索真实世界中连花清瘟胶囊（颗粒）治疗肺部感染的疗效评价

张利丹, 谢雁鸣^*, 孙梦华

中国中医科学院中医临床基础医学研究所,北京 100700

收稿日期:2021-03-26 出版日期:2022-02-15 发布日期:2022-02-15
通讯作者: ^*谢雁鸣,女,研究员·博导,中医临床评价方法。E-mail：ktzu2018@163.com
作者简介:张利丹,女,硕士,中药上市后评价。
基金资助:
国家重点研发计划（2018YFC1707400）

Therapeutic effects of Lianhua Qingwen capsules(granules) against pulmonary infections based on data mining in the real world

ZHANG Lidan, XIE Yanming^*, SUN Menghua

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2021-03-26 Online:2022-02-15 Published:2022-02-15

摘要/Abstract

摘要： 目的探讨肺部感染患者使用或未使用连花清瘟胶囊（颗粒）的疗效评价差异。方法提取全国18家大型三级甲等医院的医院信息管理系统（HIS）数据库中肺部感染患者诊疗数据,采用非随机对照匹配设计的方法对2004年9月15日至2015年12月15日使用连花清瘟胶囊（颗粒）（连花清瘟组1 395例）和未使用连花清瘟胶囊（颗粒）（对照组1 395例）共计2 790例的肺部感染患者按照年龄分段、性别相同的标准进行1∶1匹配,通过倾向性评分的方法平衡混杂因素,对重新整合后的患者治疗结局进行对比分析。结果控制混杂因素之后,联合使用连花清瘟胶囊（颗粒）相对于未联合使用连花清瘟胶囊（颗粒）组,其针对肺部感染患者的疗效存在统计学差异。结论基于现有的真实世界电子医疗数据和研究方法认为,使用连花清瘟胶囊（颗粒）对肺部感染具有较好的治疗效果,该研究结果仍有待前瞻性研究做进一步证实。

关键词: 连花清瘟胶囊（颗粒）, 肺部感染, 真实世界, 倾向性评分

Abstract: Objective To find out whether there is any difference in the evaluation of treatment of Lianhua Qingwen capsules(granules) used in patients with pulmonary infections. Methods The data on diagnosis and treatment of patients with pulmonary infections was retrieved from the hospital information system (HIS) of 18 large hospitals in China. A non-randomized control matching design was used to study the therapeutic effect among 2 790 aged- and gender-matched lung infection patients treated with or without Lianhua Qingwen capsules(granules) between September 15, 2004 and December 15, 2015. A propensity score was used to balance confounding factors and to compare the outcomes of regrouped patients. Results After controlling for confounding factors, there was statistically significant difference in Evaluation of treatment between the combined use of Lianhua Qingwen capsules(granules) and the non-combined use. Conclusion Based on the real-world electronic medical data and research methods currently available, it is believed that the use of Lianhua Qingwen capsules(granules) in the treatment of pulmonary infections has a good therapeutic effect. However, the results of this research need to be confirmed by prospective studies.

Key words: Lianhua Qingwen capsules(granules), pulmonary infection, real world, the propensity score

中图分类号:

R969.3

张利丹, 谢雁鸣, 孙梦华. 倾向性评分探索真实世界中连花清瘟胶囊（颗粒）治疗肺部感染的疗效评价[J]. 中国药物警戒, 2022, 19(2): 126-129.

ZHANG Lidan, XIE Yanming, SUN Menghua. Therapeutic effects of Lianhua Qingwen capsules(granules) against pulmonary infections based on data mining in the real world[J]. Chinese Journal of Pharmacovigilance, 2022, 19(2): 126-129.

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倾向性评分探索真实世界中连花清瘟胶囊（颗粒）治疗肺部感染的疗效评价

Therapeutic effects of Lianhua Qingwen capsules(granules) against pulmonary infections based on data mining in the real world

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