中国药物警戒 ›› 2022, Vol. 19 ›› Issue (2): 130-133.
DOI: 10.19803/j.1672-8629.2022.02.04

• 真实世界中成药用药方案研究专栏 • 上一篇    下一篇

4832例生脉注射液治疗心力衰竭患者临床特征及联合用药数据挖掘

孙春全, 谢雁鸣1,*, 侯恒悦2   

  1. 1中国中医科学院 中医临床基础医学研究所,北京 100700;
    2中国人民大学统计学院,北京 100872
  • 收稿日期:2021-02-26 出版日期:2022-02-15 发布日期:2022-02-15
  • 通讯作者: *谢雁鸣,女,首席研究员·博导,中药上市后评价研究及老年病的中医诊疗规律。E-mail：ktzu2018@163.com
  • 作者简介:孙春全,男,博士,老年病的中医诊疗规律。
  • 基金资助:
    国家重点研发计划(2018YFC1707400)

Data mining of clinical characteristics and combined medications of 4 832 patients with heart failure treated with Shengmai injection

SUN Chunquan1, XIE Yanming1,*, HOU Hengyue2   

  1. 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2School of Statistics, Renmin University of China, Beijing 100872, China
  • Received:2021-02-26 Online:2022-02-15 Published:2022-02-15

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摘要： 目的 以真实世界中的医院信息管理系统（HIS）为依托,深入研究生脉注射液（SMI）治疗心力衰竭的临床特征及联合用药规律。方法 利用R软件对HIS数据库中2002年1月1日至2016年12月31日期间4 832例SMI治疗心力衰竭患者的数据进行统计分析。结果 男性患者2 273例,女性患者2 499例,60例患者缺失;患者的平均年龄为（72.57±13.45）岁;患者的平均住院天数为（22.18±19.28）d;SMI的主要用药途径为静脉滴注（3 915例,占81.02%）;静脉滴注患者的单次使用剂量平均为（57.16±20.16）mL;平均用药疗程为（4.76±6.16）d。最为常见的用药组合为螺内酯+呋塞米、乙酰水杨酸+螺内酯+呋塞米等。结论 初步了解真实世界中心衰患者的基本临床特征、SMI的用药特征,为指导临床医生合理联合应用SMI提供参考。

关键词: 真实世界研究, 生脉注射液, 心力衰竭, 医院信息管理系统, 临床特征

Abstract: Objective To make an in-depth study on the clinical characteristics of Shengmai Injection (SMI) in the treatment of heart failure and the patterns of combined medications based on the real world data from the hospital information system (HIS). Methods R software was used to analyze the data on 4 832 patients with heart failure in HIS databases from January 1, 2002 to December 31, 2016. Results There were 2 273 male patients and 2 499 female ones, but the data on gender was missing for 60 patients. The age of the patients averaged (72.57±13.45) years old and the length of hospital stay averaged (22.18±19.28) days. The main route of administration of SMI was intravenous drip (3 915 cases, accounting for 81.02%). The average single dose was (57.16±20.16) mL, and the average course of treatment was (4.76±6.16) days. The most commonly-used drug combinations included spironolactone+furosemide, and acetylsalicylic acid+spironolactone+furosemide. Conclusion This real world study of combined medications for heart failure has shed light on the basic clinical characteristics of patients with heart failure in the real world and the medication characteristics of SMI and provided reference for clinicians.

Key words: real world study, Shengmai injection, heart failure, hospital information system, clinical characteristics

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