真实世界老年患者使用刺五加注射液的临床分析

doi:10.19803/j.1672-8629.2022.09.02

摘要/Abstract

摘要： 目的基于真实世界电子医疗数据库分析老年患者使用刺五加注射液的临床应用特征,为提高临床用药合理性提供参考。方法该研究采用数据挖掘方法中的关联规则,对全国24家大型三级甲等医院信息系统2004年1月1日至2019年12月31日采集的电子医疗数据进行回顾性分析,针对年龄65岁及以上使用刺五加注射液治疗的住院患者,获得其一般情况、诊断信息、中西药联合用药等相关信息,通过统计描述与Apriori算法分析联合用药关联性。结果使用刺五加注射液的老年患者共6 561例,以65~75岁的老年人为主,男性少于女性,主要西医诊断为高血压、脑梗死、冠心病等疾病,临床常见与乙酰水杨酸、单硝酸异山梨酯、硝苯地平等药物联合使用。合并用药方面,主要与血管保护药、心脏病治疗药、钙通道阻断药等联合使用。结论刺五加注射液老年患者真实世界应用情况与该人群临床疾病诊断和药物使用情况相符,真实世界回顾性研究结果显示其临床疗效较好。临床医生可谨慎参考并加强中医诊断与辨证施治,严格按照指南与药品说明书使用刺五加注射液。

关键词: 刺五加注射液, 老年, 医院信息系统, 联合用药, 真实世界

Abstract: Objective To analyze the clinical applications of Ciwujia injection in elderly patients based on the real-world electronic medical database, and to provide reference for rational clinical medication. Methods In this study, association rules in data mining methods were used to conduct a retrospective analysis of electronic medical data collected by the information system of 24 big hospitals in China from January 1, 2004 to December 31, 2019. The basic information, diagnosis and usage of Chinese and western medicine related to inpatients aged 65 and older who had used Ciwujia injection were recorded. The Apriori algorithm was used to analyze how drugs were used in combination. Results A total of 6 561 elderly patients who had used Ciwujia injection were collected, most of whom were between 65 and 75 years old. There were fewer male patients than female ones. According to Western medicine, most of the patients were diagnosed with hypertension, cerebral infarction and coronary heart disease. Ciwujia injection was commonly used in combination with acetyl salicylic acid, isosorbide mononitrate and nifedipine. Drugs that were usually used in combination with Ciwujia injection were intended to protect blood vessels and the heart and block calcium channels. Conclusion The way Ciwujia injection is used among elder patients in the real world conforms to clinical diagnosis and drug instructions. The retrospective study shows Ciwujia injection is effective for elderly patients. Clinicians are advised to be cautious with TCM diagnosis and evidence-based medicine and prescribe Ciwujia injection in strict accordance with the guidelines and instructions.

Key words: Ciwujia injection, old age, hospital information system(HIS), drug combination, the real world

中图分类号:

R977.9

黄艳丽, 谢雁鸣, 王连心, 孙粼希, 刘峘, 庄鋆妮. 真实世界老年患者使用刺五加注射液的临床分析[J]. 中国药物警戒, 2022, 19(9): 935-939.

HUANG Yanli, XIE Yanming, WANG Lianxin, SUN Linxi, LIU Huan, ZHUANG Yunni. Clinical applications of Ciwujia injection in elderly patients in the real world[J]. Chinese Journal of Pharmacovigilance, 2022, 19(9): 935-939.

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