注射用万古霉素致儿童中性粒细胞缺乏1例分析

doi:10.19803/j.1672-8629.20210813

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (1): 106-109.
DOI: 10.19803/j.1672-8629.20210813

注射用万古霉素致儿童中性粒细胞缺乏1例分析

曹小雨¹, 王莹², 王婧雯³, 杨瑞霞¹, 葛洁^3,*

¹西安医学院第二附属学院药剂科,陕西西安 710038;
²三原县人民医院药剂科,陕西咸阳 713800;
³空军军医大学第一附属医院药剂科,陕西西安710032

收稿日期:2021-08-23 发布日期:2023-01-19
通讯作者: ^*葛洁,女,硕士,主管药师,临床药学。E-mail: jie3510071@qq.com
作者简介:曹小雨,女,硕士,药师,临床药学。
基金资助:
国家自然科学基金资助项目（72074218）

Analysis of agranulocytosis in a child induced by vancomycin injection

CAO Xiaoyu¹, WANG Ying², WANG Jingwen³, YANG Ruixia¹, GE Jie^3,*

¹Department of Pharmacy, the Second Affiliated Hospital of Xi'an Medical University, Xi'an Shaanxi 710038, China;
²Department of Pharmacy, Sanyuan County People's Hospital, Xianyang Shaanxi 713800, China;
³*Department of Pharmacy, the First Affiliated Hospital, Air Force Military Medical University, Xi'an Shaanxi 710032, China;

Received:2021-08-23 Published:2023-01-19

摘要/Abstract

摘要： 目的为注射用万古霉素引起儿童中性粒细胞减少或缺乏的药品不良反应提供证据。方法分析我院1例4岁感染性心内膜炎患儿应用注射用万古霉素后导致中性粒细胞缺乏的案例,并回顾国内外相关文献。结果检索国内外相关报道并结合本文1例患儿分析,5例患儿在使用注射用万古霉素治疗后均出现不同程度的中性粒细胞减少或缺乏,停药或减量后中性粒细胞逐渐恢复;患儿中性粒细胞减少可能与万古霉素在体内蓄积有关。结论儿童应用注射用万古霉素应严格监测血药浓度,发生药品不良反应时需及时调整剂量或停药;必要时给予对症处置。

关键词: 万古霉素, 中性粒细胞减少/缺乏, 儿童, 药品不良反应

Abstract: Objective To provide reference for vancomycin injection induced adverse reaction—neutropenia/agranulocytosis. Methods A case report of four-year-old girl with agranulocytosis caused by vancomycin injection was analyzed by reviewing the related literature. Results A total of four related domestic and foreign reports were retrieved in this paper. It was found that all the five cases suffered from agranulocytosis or neutropenia to different extents after receiving vancomycin injection, and that the patients gradually recovered after vancomycin withdrawal or dosage reduction. Neutropenia in children might be related to the accumulation of vancomycin. Conclusion Routine plasma drug concentrations should be closely monitored when children receive vancomycin injection. The dosage of vancomycin should be reduced or stopped in case of agranulocytosis or neutropenia. If necessary, symptomatic treatments should be given.

Key words: vancomycin, agranulocytosis/neutropenia, children, adverse drug reaction

中图分类号:

R978
R994.11

曹小雨, 王莹, 王婧雯, 杨瑞霞, 葛洁. 注射用万古霉素致儿童中性粒细胞缺乏1例分析[J]. 中国药物警戒, 2023, 20(1): 106-109.

CAO Xiaoyu, WANG Ying, WANG Jingwen, YANG Ruixia, GE Jie. Analysis of agranulocytosis in a child induced by vancomycin injection[J]. Chinese Journal of Pharmacovigilance, 2023, 20(1): 106-109.

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注射用万古霉素致儿童中性粒细胞缺乏1例分析

Analysis of agranulocytosis in a child induced by vancomycin injection

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