代谢酶和转运体介导的草药-化学药相互作用安全性研究进展

doi:10.19803/j.1672-8629.2021.01.04

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (1): 18-23.
DOI: 10.19803/j.1672-8629.2021.01.04

• 复方与联合用药安全性评价专栏(第一辑) • 上一篇下一篇

代谢酶和转运体介导的草药-化学药相互作用安全性研究进展

王姝廷¹, 邱彩霞¹, 王凤林^2,*, 靳洪涛^1,3,*

¹中国医学科学院北京协和医学院药物研究所新药安全评价研究中心,北京 100050;
²解放军总医院第三医学中心医学实验中心,北京 100039;
³北京协和建昊医药技术开发有限责任公司,北京 100176

收稿日期:2020-09-18 修回日期:2021-01-18 出版日期:2021-01-15 发布日期:2021-01-18
通讯作者: ^*王凤林,男,本科,主管药师,合理安全用药。E-mail:wangfl@hotmail.com;靳洪涛,男,博士·硕导,研究员,药物毒害因素识别及有效防控。E-mail:jinhongtao@imm.ac.cn
作者简介:王姝廷,男,在读硕士,药物肝脏毒害因素识别及有效防控。
基金资助:
十三五重大新药创制专项(2018ZX09201017-5; 2018ZX09711001-002-001):吸入毒性和儿童用药等特色创新药物安全性评价关键技术研究; 新技术新方法在药物毒性中的应用; 中国毒理学会临床毒理课题(CST2019CT105):基于临床风险信号的毒理学评价路径研究

Research Progress in Safety of Herb-drug Interactions Mediated by Metabolizing Enzymes and Transporters

WANG Shuting¹, QIU Caixia¹, WANG Fenglin^2,*, JIN Hongtao^1,3,*

¹New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China;
²Medical Experimental Center,the Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China;
³China Beijing Union-Genius Pharmaceutical Technology Co.,Ltd.,Beijing 100176,China

Received:2020-09-18 Revised:2021-01-18 Online:2021-01-15 Published:2021-01-18

摘要/Abstract

摘要： 目的分析药物代谢酶和转运体介导的草药-化学药相互作用(herb-drug interactions,HDIs)和不良反应发生机制,总结常用草药与化学药物之间潜在相互作用的信息。方法通过PubMed、Web of Science和中国知网等文献检索数据库,对草药、转运体、代谢酶等关键词进行文献检索。结果草药与化学药合用并不总是有益、安全的,草药可以介导药物代谢酶和转运体的活性来发生HDIs,这会导致一些不良反应发生的潜在风险。结论不恰当的草药与化学药合用会增加化学药不良反应的发生几率,这种草药-化学药介导的相互作用引起的不良反应值得临床医生、制药企业和药品监管部门关注。

关键词: 草药, 代谢酶, 转运体, 草药-化学药相互作用, 核受体

Abstract: Objective To analyze the possible mechanism by which drug metabolizing enzymes and transporters mediate herb-drug interactions (HDIs) and causes of adverse reactions,and summarize the data about potential interactions between commonly used herbs and conventional chemical drugs.Methods Such databases as PubMed,Web of Science and CNKI were searched with "herbs" "transporters" and "metabolizing enzymes" as the key words.Results The use of herbs combined with chemical drugs was not always conducive and safe.Herbs can mediate the activity of drug metabolic enzymes and transporters to produce HDIs,which can potentially lead to risks of adverse reactions.Conclusion Inappropriate combination of herbs and drugs will increase the chance of potential adverse reactions,and adverse reactions caused by herb-drug interactions deserve the attention of clinicians,pharmaceutical companies and drug regulators.

Key words: herb, drug metabolizing enzymes, transporters, herb-drug interactions(HDIs), nuclear receptor

中图分类号:

R969.2

王姝廷, 邱彩霞, 王凤林, 靳洪涛. 代谢酶和转运体介导的草药-化学药相互作用安全性研究进展[J]. 中国药物警戒, 2021, 18(1): 18-23.

WANG Shuting, QIU Caixia, WANG Fenglin, JIN Hongtao. Research Progress in Safety of Herb-drug Interactions Mediated by Metabolizing Enzymes and Transporters[J]. Chinese Journal of Pharmacovigilance, 2021, 18(1): 18-23.

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代谢酶和转运体介导的草药-化学药相互作用安全性研究进展

Research Progress in Safety of Herb-drug Interactions Mediated by Metabolizing Enzymes and Transporters

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