基于CiteSpace知识图谱的中草药致肝损伤研究热点与趋势分析

doi:10.19803/j.1672-8629.20230137

摘要/Abstract

摘要： 目的对中草药致肝损伤的文献进行可视化分析,探索该学科领域的发展现状及趋势,预测未来研究方向。方法检索中国知网、Web of Science数据库自建库至2023年2月28日公开发表的关于中草药致肝损伤相关研究文献,利用 CiteSpace 6.1.R6软件对年发文量、作者、机构、关键词进行可视化分析,探讨该领域的研究热点、研究现状及发展趋势。结果共纳入2 393篇中文文献和488篇英文文献,年发文量整体呈上升趋势;核心作者共71位,对该领域的研究已经形成多个核心研究团队,但各团队间缺乏稳定合作;机构合作在英文文献中较中文文献更加紧密,存在一定跨区域合作;研究热点集中在中草药致肝损伤的化学成分、作用机制、炮制配伍减毒及临床评价与风险防控。结论中草药致肝损伤领域的研究热度逐年上升,基于多组学技术探索中草药致肝损伤作用机制和临床评价指标可能是以后重点研究的方向。

关键词: 肝损伤, 中草药, CiteSpace, 可视化分析, 文献计量学

Abstract: Objective To explore the development status and trend of herb-induced liver injury, and predict the future research direction by analyze the literature through visual analysis. Methods The research literature on herb-induced liver injury published from database inception to February 28, 2023 was retrieved from CNKI and Web of Science. CiteSpace 6.1.R6 was used to visually analyze the annual number of papers, authors, institutions and keywords, so as to discuss the research hotspots, status and development trends in this field. Results A total of 2 393 Chinese articles and 488 English articles were included, and the number of publications increased year by year with a stable trend. There were 71 core authors, forming several research teams, while there was little cooperation among them. Institutional cooperation is closer in English literature than in Chinese literature, and there are some cross-regional cooperations. Recent research focuses on the chemical components, mechanism, the toxicity reduction of TCM processing and compatibility, clinical evaluation, prevention and control of herb-induced liver injury. Conclusion The research popularity in the field of herb-induced liver injury has increased year by year, and exploring the mechanism and clinical evaluation indexes based on multi-omics technology may be the future focus of research.

Key words: liver injury, Chinese herbal medicine, CiteSpace, visualization analysis, bibliometrics

中图分类号:

R917

徐帅, 陈恂, 卞昊宇, 赵玉清, 张立平. 基于CiteSpace知识图谱的中草药致肝损伤研究热点与趋势分析[J]. 中国药物警戒, 2023, 20(5): 560-567.

XU Shuai, CHEN Xun, BIAN Haoyu, ZHAO Yuqing, ZHANG Liping. Research hotspots and trends of herb-induced liver injury based on CiteSpace knowledge maps[J]. Chinese Journal of Pharmacovigilance, 2023, 20(5): 560-567.

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